Postdoctoral Research Assistant

You will join the Centre for Medicines Discovery at the Nuffield Department of Medicine, and be part of the wider MRC Centre for Research Excellence REACT, consisting of groups located at King’s College London, University of Edinburg and University of Oxford. The Centre aims to develop the first therapies to stimulate heart repair and regeneration in patients with heart failure, for which there are currently no effective treatments. REACT is a joint initiative of King’s College London (Prof. Mauro Giacca), University of Oxford (Prof. Paul Riley and Prof. Robin Choudhury), and University of Edinburgh (Prof. Andrew Baker).

 

This project will establish routine cell surface proteome analysis using subcellular fractionation techniques, such as density gradient centrifugation and surface biotinylation followed by enrichment, to explore the surface proteome in heart-specific cell lines and primary tissue. It will utilize disease model systems to characterize unique cell surface signatures for cardiomyocytes, coronary endothelial cells, and fibroblasts. By focusing on unique cell-specific receptors, outcomes will inform the development of targeted drug delivery strategies utilizing RNA therapeutics. This research will contribute to a deeper understanding of myocardial regeneration, neoangiogenesis, immunomodulation, and anti-fibrosis at the molecular level, with spatial resolution.

 

To be successful in this role, you will  hold a relevant PhD/Dphil,(or close to completion) in a relevant discipline together with experience in LC-MS/MS proteomics. You will have experience in advanced biochemical methods for surface proteomics/subcellular fractionation (i.e. surface biotinylating, gradient centrifugation, and be proficient in advanced data analysis (i.e. R, Python). Excellent analytical, organisational, and problem-solving skills are essential, along with the ability to work independently and as part of a collaborative team. You should be proactive in developing new methods, contributing to projects, and disseminating results through publications and conferences.

 

Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.

 

This position is offered full time on a fixed term contract until 31 May 2027 and is funded by the MRC.

 

Only applications received before 12 midday on 2 June 2025 will be considered. Please quote 179531 on all correspondence.

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