Research Associate

Job description:

We are seeking a highly motivated Postdoctoral Research Associate to join the Ismail Lab at the University of Sheffield, within the Division of Clinical Medicine and the Bateson Centre for Disease Mechanisms. This exciting, Versus Arthritis-funded position focuses on understanding how mechanical injury in connective tissues drives inflammation and damage in musculoskeletal diseases such as osteoarthritis and identify early biomakrkers and therapeutic targets for the disease. The successful candidate will contribute to a multidisciplinary project involving chemoproteomics, spatial transcriptomics, imaging, and animal models. Key responsibilities include processing human tissue samples for mass spectrometry, developing activity-based assays, and performing compound library screening. The role also involves the use of inducible murine models of osteoarthritis and applying advanced imaging and transcriptomic techniques to assess tissue damage and inflammation. The lab also employs zebrafish-based high-throughput screening and live imaging platforms.

Applicants should hold a PhD in a relevant field (or have equivalent experience), and have experience in cellular signalling, mass spectrometry, murine osteoarthritis models, molecular biology, and genetic manipulation techniques such as CRISPR/Cas9. Skills in bioinformatics, spatial transcriptomics, and fluorescence imaging are highly desirable. The ideal candidate will be an independent and collaborative researcher with a strong interest in musculoskeletal biology and inflammation. This is a unique opportunity to contribute to impactful translational research in a vibrant, collaborative environment. Team spirit and a strong work ethic are essential in this diverse team who values teamwork and cohesion. Excellent communication and interpersonal skills are expected.

What We Offer:

The University of Sheffield is a remarkable place to work. Our people are at the heart of everything we do. Their diverse backgrounds, abilities and beliefs make Sheffield a world-class university.

We offer a fantastic range of benefits including a highly competitive annual leave entitlement (with the ability to purchase more), a generous pensions scheme, flexible working opportunities, a commitment to your development and wellbeing, a wide range of retail discounts, and much more.

Find out more at sheffield.ac.uk/jobs/benefits and join us to become part of something special.

The School of Medicine and Population Health at the University of Sheffield offers a stimulating and collaborative research environment within a Russell Group university. The School is home to cutting-edge research across diverse areas, from fundamental cell and molecular biology to public health and clinical trials, offering opportunities to contribute to impactful discoveries that address global health challenges. This role offers a competitive salary and benefits package commensurate with experience and the chance to work at a world-renowned institution in a beautiful and vibrant city in the heart of the UK. We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.

We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.

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