PhD Studentship: Engineering stable designer chromosomes

Primary supervisor - Dr Conrad Nieduszynski

Recent technological advances allow us to design and construct entire chromosomes, allowing unprecedented potential for the creation of cellular machines. These synthetic designer de novo chromosomes allow us to address fundamental biological questions, systematically re-engineer genetic components, incorporate large-scale metabolic pathways, and ultimately engineer programmable organisms. To fulfil this potential, it is crucial to understand the design principals for stable maintenance of synthetic chromosomes. We have recently contributed to the design, build and test of the first non-native eukaryotic chromosome, called a neoChromosome. This PhD project builds upon this work to clarify and test the design principles for stable maintenance of fully synthetic chromosomes within eukaryotic cells. We offer a highly collaborative multi-disciplinary PhD between the Nieduszynski (chromosome biology; technology development) and Grandellis (engineering biology; molecular biology automation) groups. The student will work in a rapidly developing field and gain a unique expertise in engineering biology, technology development and automation - skills that are in high demand for modern biological research in both academia and industry. The project will be conducted at the Earlham Institute, a BBSRC-supported, world-class research centre for bioinformatics and genome biology. The student will have access to training and career development opportunities at the Earlham Institute and on the Norwich Research Park as part of the Norwich Biosciences Doctoral Training Partnership.

The Norwich Research Park Biosciences Doctoral Training Programme (NRPDTP) is offering fully funded studentships for October 2026 entry. The programme offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship placement (PIPS) during their study. The placement offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team.

This project has been shortlisted for funding by the NRPDTP. Shortlisted applicants will be interviewed on 3,4 or 5 February 2026.

Visit our website for further information on eligibility and how to apply: https://biodtp.norwichresearchpark.ac.uk/.

Mode of study

Full time

Start date

1 October 2026

Additional Funding Information

This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD CASE studentship with Inspiralis Limited. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2025/6 stipend rate: £20,780), and a Research Training Support Grant of £5,000pa for each year of the studentship.

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