PhD Studentship: Synergistic Efficacy of a Monoclonal Antibody Therapy with Colistin Against AMR Acinetobacter baumannii

Supervisors:

Prof. Jeremy Brown

Prof. Bart Hoogenboom

Abstract

This project explores a novel therapeutic strategy for Acinetobacter baumannii, a top-priority AMR pathogen, by investigating the synergistic effects of monoclonal antibodies and colistin. Building on extensive preliminary data, the project aims to uncover the mechanisms behind this synergy using advanced biophysical and molecular techniques. The findings will lay the groundwork for clinical application and contribute to the development of targeted therapies for resistant bacterial infections.

Approach and Methods

• Atomic force microscopy (AFM) for molecular-scale visualisation of living bacteria.
• In vitro assays to measure growth and stress responses.
• RNA-seq to analyse gene expression under treatment conditions.

Impact and Outlook

This project will

• Establish mechanistic foundations for a new therapeutic strategy.
• Support clinical translation of antibody–antibiotic combinations.
• Contribute to global AMR mitigation efforts.

Training and Student Development

The successful applicant will gain expertise in:

• Biophysical imaging (AFM, microscopy)
• Microbiology and molecular biology
• RNA sequencing and data analysis
• Interdisciplinary collaboration across clinical and physical sciences

Research Environment

Hoogenboom Lab: Pioneers in AFM imaging of bacteria, supported by BBSRC and Wellcome.

Brown Lab: Leader in pneumonia pathogenesis, equipped for microbiology and screening assays, MRC and Wellcome-funded.

Both labs promote an open, collaborative culture and have a strong track record of PhD supervision.

Desirable Prior Experience

Some prior experience in basic microbiology, immunology, and/or microscopy would be an advantage, but not essential.

How to apply

This project is offered as part of the Centre for Doctoral Training in Engineering Solutions for Antimicrobial Resistance. Further details about the CDT and programme can be found at AMR CDT webiste  

Applications should be submitted by 12^th January 2026.

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