PhD Studentship: Engineering Real-World Surfaces to Control the Acquisition of Antimicrobial Resistance

Supervisors:

Prof. Giorgio Volpe

Prof. Lena Ciric

Abstract

Horizontal gene transfer (HGT) is a major driver of antimicrobial resistance (AMR), yet most research focuses on well-mixed lab cultures rather than the structured biofilms found in real-world environments. This project investigates how engineered surface topographies influence HGT dynamics, aiming to develop design principles for materials that suppress resistance gene transfer. Combining biophysics, microbiology, and materials science, the project will generate insights into how physical environments can be harnessed to control AMR.

Approach and Methods

• Soft lithography and microfabrication to create defined surface landscapes.
  • Mating assays between resistant and sensitive Enterobacteriaceae strains.
  • Live-cell imaging and fluorescent plasmid tracking.
  • Quantitative image analysis to assess spatial dynamics of gene transfer.

Impact and Outlook

This project will:

• Establish proof of concept for surface-based AMR control.
  • Inform the design of antimicrobial hospital surfaces and medical devices.
  • Contribute to sustainable strategies for AMR mitigation.

Training and Student Development

The successful applicant will gain expertise in:

• Microbial genetics and fluorescence imaging
  • Microfabrication and surface engineering
  • Quantitative microscopy and data analysis
  • Interdisciplinary collaboration across microbiology, engineering, and biophysics

Research Environment

Volpe Lab: Experts in active matter, microscopy and microfabrication, with a strong interdisciplinary focus.
Ciric Lab: Leaders in healthy infrastructure and microbial surface interactions.
Both labs foster collaborative, cross-disciplinary research and have a strong record of PhD supervision.

Desirable Prior Experience

Experimental biophysics and soft matter, optical microscopy, numerical methods, molecular biology methods (e.g. cloning, PCR) and bacterial plasmid mating.

How to apply

This project is offered as part of the Centre for Doctoral Training in Engineering Solutions for Antimicrobial Resistance. Further details about the CDT and programme can be found at AMR CDT webiste  

Applications should be submitted by 12^th January 2026.

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