Postdoctoral Research Assistant - UOD2127

The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 40 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

We are recruiting for an exceptional individual to join us as a Post-Doctoral Research Association within the Masson and Muqit Groups to conduct structural mass spectrometry for drug discovery on a Parkinson’s Disease target. This is a fixed-term appointment for 1 year.

This post-doctoral researcher will join the labs of Dr Glenn Masson and Professor Miratul Muqit at the School of Medicine, and MRC Protein Phosphorylation and Ubiquitin Unit (MRC PPU), Dundee, respectively. Candidates with expertise in structural mass spectrometry, peptide chemistry, high-throughput screening and therapeutic drug development will investigate novel chemical matter for the discovery of novel therapeutics for the treatment of Parkison's Disease (PD).

The Masson and Muqit labs work together to understand critical stress sensing pathways in the mitochondria which may contribute to the progression of PD. Recent drug discovery efforts have provided novel routes for drug development which require better characterisation structurally using our cutting-edge mass spectrometry facilities at the University of Dundee.

Researchers at the School of Medicine and the MRC PPU benefit from an interdisciplinary environment with strong links to industry and the opportunity to play a part in "from bench to bedside" drug discovery programmes. They will gain training in advanced techniques, have access to cutting edge instrumentation and materials, and will work with international consortia of

Your priorities will include:

• Determination of binding sites of small molecule compounds on proteins using structural mass spectrometry such as native mass spectrometry and HDX-MS
• Development of novel methods in structural mass spectrometry for drug discovery.
• Instrument maintenance and data benchmarking
• Dissemination of protocols and data openly and through formal peer-reviewed publications.
• Advising and mentoring undergraduate and PhD students.

Who we’re looking for:

• A PhD in biochemistry, biophysics, structural mass spectrometry, proteomics or a related discipline with an outstanding academic track record and publication record. (Essential)
• Experience and publications on structural mass spectrometry methods in international journals. (Essential)
• Experience with a Waters mass spectrometry instruments and related Instrumentation (fluidics systems etc.). (Essential)
• Experience with assessing drug binding using structural mass spectrometry methods. (Desirable)
• Experience with peptide chemistry. (Desirable)

We are one of the UK’s leading universities, internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Our purpose is to transform lives, locally and globally, which we do as a community of staff (Professional Services and academic Schools), students and alumni. Professional Services directorates are key to delivering the University strategy and driving change across the University.

For further information about this position please contact Dr Glenn Masson at gmasson001@dundee.ac.uk. To find out more about the Masson group please visit https://www.dundee.ac.uk/people/glenn-masson.

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