Senior Laboratory Research Scientist - Metabolomics Specialist

Location: The Francis Crick Institute, London

Short summary

This role in the Metabolomics Scientific Technology Platform (STP) will encompass discovery and targeted metabolomics in the context of biological research, as well as development of new methods to push the boundaries of metabolomics research. The post provides a unique opportunity to work with cutting edge metabolomics techniques and to become deeply involved in the diverse biological research across the Crick, from large clinical cohort discovery studies to intricate analysis of metabolic activity.

Key Responsibilities 

These include but are not limited to: 

• Metabolomics, lipidomics, and mass spectrometry projects (40%). Operation and maintenance of mass spectrometers – particularly LC-MS and GC-MS. Driving metabolomics projects, including experimental design, stable isotope labelling techniques, and novel method development.
• Data analysis and computational work (35%). Effective use of data analysis software to process and analyse MS data, including statistical analyses (i.e. univariate and multivariate analyses).
• Training (15%). Training of others in the operation of the LC-MS & GC-MS instrumentation and metabolomics/lipidomics workflows.
• Laboratory management (10%). Maintenance of successful day to day operation of the laboratory, including maintenance of safety standards, purchasing, and general organisation, among others.

About you

You will have: 

• Ph.D. or equivalent, in Metabolomics, Biochemistry, Analytical Chemistry, or other relevant, related discipline.*
• Significant experience in operation, maintenance, and troubleshooting of hyphenated-mass spectrometry (in particular, LC-MS & GC-MS).*
• Significant experience in performance of metabolomics/lipidomics experiments (including experimental design, metabolite extraction, sample preparation, data acquisition, and method development).* Stable isotope labelling experience is highly desirable.
• Experience in relevant data processing, analysis, and statistics (including MS/metabolomics software workflows, targeted and profiling approaches, univariate and multivariate analyses, power calculations, etc).*
• Experience in design/implementation of new analytical methods.
• Knowledge of experimental design and metabolomics procedures in the context of large cohort studies.
• Ability to work with day-to-day independence with good oral and written communication skills. 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

To apply for this role, please click on the 'Apply' button above.

Advert information