Senior Research Technician

About us

The UCL Huntington’s Disease Centre sits within the Department of Neurodegenerative Disease at the UCL Queen Square Institute of Neurology. The Department is internationally recognised for its research into neurodegenerative diseases causing dementia and related disorders, with a strong emphasis on understanding the genetic, molecular, cellular and neuropathological mechanisms that drive disease, and on linking these mechanisms to clinical outcomes.

The UCL Huntington’s Disease Centre is led by Professor Sarah Tabrizi (Director) and Professor Gillian Bates (Co‑Director). Established in 2015 in a purpose‑built environment, the Centre brings together laboratory‑based mechanistic research and clinical neuroscience to enable the translation of fundamental discoveries into early‑phase, first‑in‑human studies. The Centre integrates preclinical research, biomarker development and clinical trial delivery, including proof‑of‑concept studies conducted through the Leonard Wolfson Experimental Neurology Centre, ahead of larger multi‑centre phase II and III clinical trials.

About the role

You will work on Cure Huntington's Disease Initiative (CHDI) Foundation and UK DRI and Medical Research Council (MRC) funded projects within Professor Sarah Tabrizi’s research group at the Huntington’s Disease Centre. This is a key role within a world leading research Centre, and you will contribute to a programme of work aimed at understanding key molecular mechanisms underlying Huntington’s disease (HD) pathogenesis in post-mitotic neuronal systems.

You will also be responsible for managing the day-to-day running of the lab. This will involve stock-taking, replenishment of shared laboratory consumables, coordinating tissue culture rotas, and assisting the Lab Manager with inspections, risk assessment, and other tasks as required.

The post is available from 01 June 2026 and funded by research grant funding from CHDI and the MRC until 31 August 2028 in the first instance.

If you need reasonable adjustments or a more accessible format to apply for this job online, or have any queries regarding the application process, please contact the Institute of Neurology HR Team (ion.hradmin@ucl.ac.uk).

For informal enquiries about the role please contact Dr Marwa Elmasri (email: m.elmasri@ucl.ac.uk).

For a full job description please visit UCL’s online recruitment portal (https://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs) and search using vacancy reference B02-10480. To apply, please upload a current CV, complete the online application form, and use the supporting statement section or upload a cover letter to outline how you meet the essential and desirable criteria for the role. Please do not upload any additional attachments as these will not be considered by the selection panel.

About you

You will have a PhD or other post-graduate qualification in biological sciences or related subject, extensive experience of working in experimental laboratory research, and iPSC culture experience. Molecular biology experience such as PCR, qPCR, DNA/RNA extraction, immunostaining and immunoprecipitation is essential, as is the ability to troubleshoot experiments to identify effective solutions where no in-house methods or protocols exist. Experience in DNA methylation techniques, knowledge of Nuclei isolations and FANS, and an understanding of bioinformatics/data analysis of long-read sequencing, RNA-seq, or methylation is desirable.

This role meets the eligibility requirements for a skilled worker certificate of sponsorship or a global talent visa under UK Visas and Immigration legislation. Therefore, UCL welcomes applications from international applicants who require a visa.

What we offer

As well as the exciting opportunities this role presents, we also offer some great benefits; visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more.

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