Research Fellow

About the job:

We are seeking a Research Fellow to lead the computational chemistry aspects of a BBSRC-funded collaborative project ‘Unlocking GPCR Signalling Bias: A Multiscale Approach to GPR84 and Beyond’. The role-holder will work closely with medicinal chemists at University of Oxford and pharmacologists at University of Glasgow, applying virtual screening, machine learning, AI-driven generative chemistry, pharmacophore modelling, and molecular dynamics simulations to design novel GPR84 ligands with predictable signalling bias profiles.

About The Person

The successful candidate must have, and your application should clearly demonstrate that you meet the following essential criteria:

• Hold or be about to obtain* (must be obtained* within 3 months of start date in post) PhD in computational chemistry, computational biology, structural biology, biophysics, pharmacology or related discipline.
• Significant experience in virtual screening and molecular docking.
• Experience with machine learning/AI approaches in drug discovery.
• Familiarity with generative chemistry platforms. Experience with pharmacophore modelling.
• Experience with molecular dynamics simulations. Strong scripting skills (Python, Bash).
• Experience with HPC environments
• Knowledge of GPCR structure, function, and signalling pathways.

To be successful at shortlisting stage, please ensure you clearly evidence in your application how you meet the essential and, where applicable, desirable criteria listed in the Candidate Information on our website

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