Research Assistant / Associate in Immunology

We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.

Salary
Research Assistant - £33,951 to £35,608 per annum.
Research Associate - £36,636 to £46,049 per annum.

The Role
We are excited to announce that a research assistant/research associate position is available in the Haematopoiesis and Immunogenomics Lab (HI Lab) at Newcastle University, to cover maternity leave. The postholder will join a research programme focused on understanding how human immunity is generated and regulated through haematopoiesis. Effective immune function depends on the coordinated production of specialised cell types, a process governed by complex networks of transcription factors. However, the mechanisms by which these factors maintain homeostasis in health while enabling adaptive responses to external challenges such as infection and cancer remain poorly defined.

Working within a multidisciplinary and translational research environment, the postholder will apply cutting-edge cell culture, transcriptomic, epigenetic, and genomic approaches to dissect transcription factor function and developmental pathways at single-cell resolution. This includes the use of advanced single-cell multiomics, functional genomics, and integrative computational analyses to define how transcriptional networks control immune cell differentiation and function, and how inter-individual genetic variation shapes immune responses.

A key component of the position will be the translation of mechanistic insights into novel therapeutic strategies. This includes leveraging discoveries in transcriptional and cellular regulation to inform the development of next-generation cellular therapies aimed at manipulating human immunity. These may include engineered immune cell products, dendritic cell-based immunotherapies, or approaches to enhance immune reconstitution and anti-tumour immunity in the context of transplantation, infection, and cancer.

The postholder will contribute to the design and execution of experiments, analysis of high-dimensional datasets, and dissemination of findings through high-impact publications and presentations.

Experience in cell culture, multi-parameter flow cytometry and single cell technologies is critical. Experience in industry is desirable. The applicant must hold a PhD or be within a few months of submitting a PhD thesis.

The post is full-time, fixed-term for up to 10 months, depending on start date.

Applicants are encouraged to make informal enquiries to Dr Venetia Bigley (venetia.bigley@ncl.ac.uk).

As part of our commitment to career development for research colleagues, the University has developed 3 levels of Research Innovation Role Profiles.pdf. These profiles set out firstly the generic competencies and responsibilities expected of role holders at each level and, secondly, the general qualifications and experiences needed for entry at a particular level.

Find out more about the Faculty of Medical Sciences here: https://www.ncl.ac.uk/medical-sciences/.

Find out more about our Research Institutes here: https://www.ncl.ac.uk/medical-sciences/research/institutes/.

Contact for the post is Dr Venetia Bigley (venetia.bigley@newcastle.ac.uk).

Advert information