Research Associate in In Vitro Models of Early Development (10402)

Rosalind Franklin Institute

As a Research Associate at the Franklin, you will bring scientific knowledge and skills to deliver a specific research project and/or you will bring independent, creative science, or specific skills to a team delivering a project or program. Through this work, you will build scientific independence, develop new science and leadership skills, and establish a growing reputation externally.

In this specific role, you will establish and maintain stem cell and blastoid culture systems that model key cell fate transitions during early human development. You will generate robust, reproducible biological systems that can be interrogated across molecular, cellular and structural scales, working closely with RFI experts in mass spectrometry, cryo-electron tomography, imaging, data science and AI. The appointee will ensure that these models are suitable for high-quality, multimodal data generation, enabling the identification of candidate molecular and structural determinants of cell fate decisions. They will also play a central role in closing the prediction–validation loop: using computational predictions derived from these datasets to design, optimise and execute targeted validation experiments. More broadly, this role will help establish a biological testbed for understanding how cell fate is specified, maintained and redirected during early development. By linking stem cell and blastoid models with mass spectrometry, cryo-ET and AI-driven analysis, the work will contribute to the wider goal of building predictive, experimentally grounded models of how molecular organisation gives rise to cellular identity and developmental transitions.

Key Responsibilities

As a Research Associate you will: 

• Take care of a stem cell line, including occasional weekend work.
• Learn and apply advanced research imaging techniques to understand the structural details of the stem cell line.
• Attend scientific seminars and meetings to keep up to date with developments in stem cell culture, use and imaging.
• Disseminate results through participating in the manuscript preparation process and presenting at scientific meetings.
• Contribute to the public engagement science programme of the Franklin.
• Plan and conduct experiments, analyse and interpret results and supervised delivery of outputs (e.g. research report, patent application) in a scientific/technology area of interest.
• Work within a project team, contributing to wider projects around Franklin's key Challenges.
• Lead major contributions to outputs from research including papers, patents and both internal and external presentations.
• Support and develop others including day-to-day supervision of students or visitors in areas related to own research.
• Have supervised, staged progression to first stages of scientific independence with opportunities to further develop science and skills/experience.
• Enhance your research through collaboration with other researchers and make active contributions to exchanging of ideas through your own network.
• Be able to understand, interpret, create and communicate appropriately within a research context.
• Develop search and discovery skills and techniques.
• Be supervised by a Scientist/Senior Scientist in delivery of research outputs, either in the context of a project or Challenge or as an early career development fellow.

Before submitting your application, please ensure you read the Job Information Pack for full details of this role on our website via the above 'Apply' button.

This job description sets out the skills and experiences we believe are needed to be able to do this job but, research also tells us women are much more likely than men to take this list of requirements as absolute and self-select out of the process. If you think you can deliver this role then we want to hear from you, regardless of the boxes you did not tick.

Whilst the role requires candidates to hold a PhD/DPhil (or equivalent), we may consider candidates who have submitted their PhD/DPhil thesis, in which case the initial appointment will be made at £38,500 per annum (to be increased on completion of the PhD/DPhil qualification).

At the Rosalind Franklin Institute we also welcome applications from all around the world!

How to Apply

To be considered for this role, please upload a CV and cover letter explaining why you think you are the right person for this job. The link to apply is provided at the bottom of this page.

Closing date: The closing date for applications is 23:59 on Sunday 9th August 2026.

Interviews will be held w/c 24th August 2026.

PERIOD OF APPOINTMENT: Fixed-Term Contract (2 years)