Senior Laboratory Research Scientist (Genome Editing)

Location: The Francis Crick Institute, London

Short summary

We are seeking a highly skilled and motivated Senior Laboratory Research Scientist (SLRS) to lead and support advanced gene editing and stem cell research within SCOP. The successful candidate will play a key role in designing and implementing cutting-edge genome engineering strategies, and driving innovation across diverse research and service projects. 

Working closely with the Genetic Modification Service (GeMS) and other Science Technology Platforms (STPs), the post holder will take scientific ownership of projects in genome engineering, and contribute to the establishment of new shared resources for the research community. The role also involves providing expert training, and project guidance to collaborators.

Key Responsibilities 

These include but are not limited to:

• Delivering SCOP research and service projects, owning scientific direction and outcomes.
• Designing advanced gene editing strategies tailored to project needs.
• Working with GeMS and STPs to develop robust, innovative genome engineering solutions.
• Establishing shared methods and technologies with group leaders, strengthening institute capability.
• Staying at the forefront of CRISPR technologies through active horizon scanning and engagement.
• Training and mentoring researchers in gene editing and stem cell culture best practice.
• Engineering and maintaining high-quality iPSC and ESC lines, ensuring reproducibility and QC.
• Supporting effective lab operations, including SOPs, biosafety, resources and equipment.
• Communicating across teams, contributing to reports, collaboration and supportive research culture. 

About you

You will have:  

• Higher degree in a relevant field (PhD, MSc) with significant research experience*
• Extensive proficiency in designing and implementing gene editing strategies in human pluripotent stem cells, including generation of knockout, knock-in, or conditional alleles.*
• Extensive proficiency in molecular biology techniques, including molecular cloning, DNA/RNA extraction, PCR, RT-qPCR, and sequencing.*
• Strong background in stem cell biology, with hands-on experience in the culture and maintenance of human pluripotent stem cells (iPSCs and/or ESCs).*

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it to the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

To apply for this role, please click on the 'Apply' button above.

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