PhD Studentship: Multiomic Insights into Mitochondrial Disease - Integrating Proteomic, Genomic and Single-cell Approaches to Understand Clinical Heterogeneity in Mitochondrial Disease.

Award Summary

Open to Home students only. Fully funded with Home (UK) tuition fees and a stipend of approximately £21,805 per year, subject to annual inflationary increases.

Overview

Background

Mitochondrial diseases are among the most common inherited metabolic disorders. Despite advances in genetic diagnosis, important questions remain regarding the processes that drive disease progression and determine why some tissues are particularly vulnerable to mitochondrial dysfunction. Disease severity and progression vary considerably, even among individuals carrying the same genetic variant, and reliable biomarkers predicting clinical outcome are lacking. Improving our understanding of the biological pathways underlying mitochondrial disease is essential for the development of better diagnostic, prognostic and therapeutic approaches. Advances in proteomic, genomic and transcriptomic technologies offer powerful opportunities to address these challenges.

This fully funded studentship forms part of the LifeArc Centre for Rare Mitochondrial Diseases and will leverage access to a well-characterised, unique cohort of mitochondrial disease samples. 

Methods

You will apply single-cell proteomic and genomic technologies, integrating these data to investigate disease mechanisms at unprecedented resolution.

You will investigate how genetic variation, including differences in mtDNA variant levels between cells, influences cellular function, tissue vulnerability and disease severity. The project aims to identify molecular signatures and pathways underlying cellular dysfunction, assessing their potential as biomarkers and therapeutic targets across a broad spectrum of mitochondrial diseases. 

Supervisory Team

You will join the internationally recognised Newcastle Mitochondrial Research Group, an interdisciplinary environment spanning mitochondrial biology, a highly specialised clinical service, human genetics, proteomics, bioinformatics and translational science. 

You will be supervised by Professor Rob Taylor, Dr Sarah Pickett and Professor Gavin Hudson, receiving training in single-cell proteomics, mass spectrometry, bioinformatics, statistical genetics and multiomic data integration, providing an excellent foundation for careers in academia, biotechnology or clinical diagnostics.

Number Of Awards

1

Start Date

1st November 2026

Award Duration

3 years 

Application Closing Date

17th September 2026

Sponsor

LifeArc

Supervisors

Dr Sarah Pickett, Professor Gavin Hudson and Professor Rob Taylor

Eligibility Criteria

A 2:1 honours degree, or international equivalent, in a relevant subject. A Masters with strong research training element would be highly advantageous.

If your first language is not English, you need an overall IELTS score of 6.5 (at least 5.5 in all sub-skills) or equivalent language qualification.

How To Apply

You must apply through the University’s Apply to Newcastle Portal 

In ‘Course choice’ tab, put ‘Postgraduate Research’ in 'Type of Study', ‘Full Time’ in ‘Mode of Study’, ‘2026’ in ‘Year of Entry’, code ‘8420F’ in ‘Course Title’, blank in ‘Research Area’. Press ‘Search’, select ‘PhD Biosciences (FT)’, and save selection. 

Either upload a document or write into ‘Personal Statement’. Put code ‘BI108’ in ‘Studentship/Partnership Reference’. When prompted for research proposal, select ‘Write Proposal’. Type in the title of the research project from this advert. A research proposal is not required. You can also upload a covering letter and CV, please state how your interests and experience relate to the project.   

You must submit one application per studentship, you cannot apply for multiple studentships on one application.

Contact Details

Please contact

Dr Sarah Pickett (sarah.pickett@ncl.ac.uk)

Professor Gavin Hudson (gavin.hudson@ncl.ac.uk)

Professor Rob Taylor (robert.taylor@ncl.ac.uk)

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