Postdoctoral Researcher in Epigenetic Control of Gene Expression in Leukaemia and Haematopoiesis

Location:  Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford

An exciting opportunity has arisen for a highly motivated Postdoctoral Researcher in Leukaemia Biology and Epigenomics in the Professor Thomas Milne group. The post will investigate how chromatin proteins, nucleosomes and transcriptional regulators control gene expression and three-dimensional genome organisation.

The project will combine genome engineering and acute protein perturbation with advanced genomic approaches to investigate chromatin structure, regulatory interactions and transcription. You will be responsible for planning and carrying out your own research, generating and analysing high-quality genomic data, developing and optimising experimental approaches and preparing findings for publication. You will work both independently and collaboratively with members of the Milne group and collaborating laboratories and will contribute to the supervision and scientific development of junior researchers.

You will hold a PhD, or be close to completion with thesis submitted at the time of application, in molecular biology, genetics, epigenetics, chromatin biology or a related discipline. You will have research experience in chromatin biology, transcription or gene regulation, together with experience in mammalian cell culture, CRISPR/Cas9 genome editing and genomic or epigenomic approaches. Experience analysing genomic datasets and a strong understanding of transcriptional and chromatin regulatory mechanisms are also essential. Experience with mouse embryonic stem cells, inducible protein degradation systems, high-resolution chromosome conformation capture approaches such as Micro Capture-C, and techniques including CUT&Tag, ChIP-seq, ATAC-seq or TT-seq would be desirable.

The post is fixed-term contract until 31 March 2027, funded by the Medical Research Council.

Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application.

The closing date for this position is 12:00 noon on Friday 11 September 2026. Interviews will be held on 18 September 2026.

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