Senior Laboratory Research Scientist (Organoids)

Location: The Francis Crick Institute, London

Short summary

We are seeking a highly motivated Senior Laboratory Research Scientist to lead and support advanced organoid and 3D human model projects within SCOP. 

Working at the forefront of human in vitro model technologies, you will develop and optimize complex organoid systems including patient-derived and iPSC-derived models, while supporting collaborative research projects across the Crick. You will also play a key role in establishing new shared workflows, training researchers and helping shape the Crick’s capabilities in organoid technologies and stem cell biology.

Key Responsibilities 

These include but are not limited to:

• Leading organoid and stem cell projects across research and service activities within SCOP.
• Developing and optimising advanced 3D human models, including patient-derived and iPSC-derived organoids.
• Supporting quality control, troubleshooting and reproducibility of organoid workflows.
• Collaborating with research groups and other Science Technology Platforms across the Crick.
• Providing training, mentorship and technical guidance in organoid and stem cell techniques.
• Developing SOPs, project documentation and best-practice workflows.
• Supporting day-to-day laboratory operations and stem cell maintenance activities.

About you

You will have:  

• Higher degree in a relevant field (PhD or MSc) with research experience in stem cell biology or organoid technologies.*
• Extensive proficiency in developing, maintaining and troubleshooting complex organoid systems, including patient-derived organoids, iPSC-derived organoids, co-culture systems, spheroids, assembloids, or other advanced 3D human model*
• Strong background in stem cell biology, with hands-on experience in the culture and maintenance of human pluripotent stem cells (iPSCs and/or ESCs).*
• Experience processing primary tissue samples, such as tissue biopsies and blood.*
• Strong scientific knowledge of techniques such as immunohistochemistry, immunofluorescence, and imaging*
• Strong organisational, communication and collaborative working skills.
• Experience mentoring or supporting researchers within a laboratory environment.
• Excellent attention to detail and commitment to high-quality, reproducible science.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it to the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

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