Career Development Fellow in Bioinformatics

University of Oxford - Department of Physiology, Anatomy and Genetics

Applications are invited for a Postdoctoral Research Scientist to work within the Alzheimer’s Research UK Oxford Drug Discovery Institute (ODDI) based in the laboratory of Dr Caleb Webber. The ARUK ODDI is a new initiative which aims to translate the cutting edge academic science into drug discovery and prosecute projects in the dementia therapeutic area from target to lead status, and beyond. 

The successful candidate will work in collaboration with many ODDI-participating groups, exploiting local and publically-available data to informatically identify and evaluate dementia-relevant pathways and targets. The post is based in Dr Webber’s lab, whose members come from a mix of biological and physical science backgrounds, creating an exciting inter-disciplinary environment for research. The team develops and exploits pathway and network-based methods to identify and understand molecular process perturbed in neurological disease.

You will perform various Omics analyses across a range of patient and model data, exploiting cutting-edge network approaches to identify dementia-relevant molecular perturbations. You will be expected to interact with the many groups investigating dementia-related aetiologies across Oxford and beyond, and to harness the diversity and richness of the data that can be brought to bear on this important biomedical problem. Utilising the expertise on drug development within Oxford’s Target Discovery Institute, key targets able to modulate dementia-relevant perturbed processes will be systematically evaluated for their ability to be therapeutically targeted. A key feature of this post will be the opportunity to work with many research groups through the process of elucidating molecular aetiologies, identifying targets and early therapeutic development.

You will hold, or be near completion of, a PhD/DPhil or equivalent in DPhil in medical biology, pharmacology, informatics or a field relevant to computational genomics and target discovery. You will have an affinity for bioinformatics and computational work, expertise in molecular biology and an eye for detail; together with a record of success in an academic or pharmaceutical research setting and an ability to interact with researchers from a broad range of backgrounds.

The position is funded by Alzheimer’s Research UK for 2 years in the first instance, with a possible further year contingent on maintained funding. You will be based in the Oxford Centre for Gene Function, Parks Road, Oxford OX1 3QB.

The closing date for applications is 12.00 noon on Friday 28 October 2016.

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