Postdoctoral Research Scientist - Structural and Molecular Biology of a Transcriptional Repressor

University of Oxford - Sir William Dunn School of Pathology

Sir William Dunn School of Pathology, South Parks Road, Oxford

We are seeking to appoint a highly motivated molecular and protein scientist with a significant track record in protein expression, biophysics and structural biology, who can work independently within a multi-disciplinary group and in collaboration with key project partners. The project is available immediately until May 2019, and is funded by a Wellcome Trust ISSF award.

The purpose is to determine the structure and protein interactions of a key regulatory transcription factor and disease target protein, especially in neuro-degeneration and cancer. The project also builds on recent Wellcome trust investment in cryo-electron microscopy (Sir William Dunn School) and structure based drug development (Structural Genomics Consortia) and translational models. The main initial aim is to determine the structure of the purified human protein, bound either to DNA or to components of its complex with chromatin proteins, and to determine functional interactions using SILAC based mass spectrometry and in proof-of-concept targeting focused on cancer. All approaches build on exciting preliminary data including protein functional complementation and CRISPR/Cas9 genome editing and synthetic lethality.

The postholder will have the opportunity to both apply existing basic molecular and structural biology skills to timely delivery of high quality structural and cryo-EM data, as well as pursue mechanistic aspects of recently acquired discovery findings. Close collaborations with groups in the Sir William Dunn School (Professor Susan Lea for cryo-EM and crystallography, Professor Oreste Acuto for SILAC), SGC (Professors Bountra, and Lee, Dr Harding from Toronto, for structural based drug design) and Bristol (Professor Crump, NMR and crystallography) will be developed to rapidly progress the project. 

The successful candidate should therefore have a PhD/DPhil (or close to completion) in protein biochemistry, molecular and structural biology. Postdoctoral experience in mammalian expression systems and protein purification techniques would be essential, and surface plasmon resonance, x-ray crystallography, cryo-electron microscopy, and mass spectrometry, are all desirable.

If you are interested in this exciting role, and have the skills and experience we are looking for, please apply online. Informal discussion is encouraged ( You will be required to upload a CV and supporting statement as part of your online application.

The closing date for applications is 12.00 noon on Monday 11 December 2017. Interviews will be held week commencing 18 December 2017.

Please note that the University of Oxford's retirement policy has changed. With effect from 1 October 2017, all employees at Grade 8 and above have a retirement age of the 30 September before the 69th birthday. All employees at Grades 1-7 do not have a set retirement age. Further details are available here:

Closing Date: 11-DEC-2017 12:00

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