Postdoctoral Scientist in Cellular Electrophysiology

University of Oxford - Department of Pharmacology

Mansfield Road, Oxford

THIS IS A READVERTISEMENT - PREVIOUS APPLICANTS NEED NOT APPLY.

Professor Peter Somogyi would like to appoint a Postdoctoral Scientist in the Department of Pharmacology to join the exploration of synaptic interactions of identified cortical neurons, with particular emphasis on GABAergic mechanisms in the human cerebral cortex. The diversity of GABAergic neurons in the human cortex remains to be defined and requires investigating their input/output relationships and the dynamic plasticity of their pre- and postsynaptic interactions with pyramidal cells and each other. Presynaptic modulatory receptor mechanisms are promising drug targets, but knowledge is sparse on their action on human cortical terminals. Multipatch recording of synaptically connected neurons with pharmacological tests and analysis of signalling mechanisms and plasticity will lead to major insights.

Experience in synaptic pharmacology and intracellular recording are essential. Key duties of the post include: testing hypotheses and analysing data from in vitro electrophysiological recordings of visualised cortical neurons, reviewing, refining working hypotheses as appropriate and making discoveries. The successful candidate will have a relevant PhD/DPhil and manage their research including small-scale project management and co-ordinating multiple aspects of work. Adapting and developing scientific techniques and experimental protocols using electrophysiological and microscopic instruments are necessary. The postholder will also provide guidance to less experienced members of the research group, including postdocs, research assistants, visitors, technicians, and PhD and project students.

Evidence of designing summaries of research results, illustrations for papers and a proven ability to contribute ideas for research projects within the programme of cortical synaptic communication are necessary.

The post is fixed-term for 3 years, funded by the European Research Council.

The closing date for applications is 12.00 noon on Friday 2 February 2018.

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=132870

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South East England