Qualification Type: | PhD |
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Location: | Newcastle upon Tyne |
Funding for: | UK Students, EU Students, International Students |
Funding amount: | £18,622 |
Hours: | Full Time |
Placed On: | 20th February 2024 |
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Closes: | 30th March 2024 |
Reference: | BI081 |
Award summary
100% of home tuition fees paid and an annual stipend of £18,622.
Overview
Checkpoint inhibitors has been a standard of care for melanoma patients but approximately 30% of patients respond to these therapies. In order to improve therapy response, it is important to study the phenotype and function of the various immune cells that are involved in tumour immunity within the tumour microenvironment.
In this PhD studentship, we aim to investigate how PD-1 regulates a type of immune cell known as CD4+ T helper cell that produces IL-17 cytokine (Th17 cells). We will investigate whether Th17 cells contribute or inhibit tumour immunity in experimental murine models of melanoma currently available within the laboratory within the context of checkpoint blockade.
The student will learn cellular immunology techniques, biochemical and molecular biology techniques along with bioinformatics analysis of single cell RNA sequencing datasets and CosMx spatial transcriptomics datasets. They will also become proficient in flow cytometry and imaging techniques and learn to work with both human and murine immune cells.
Number of awards: 1
Start date: 16th September 2024
Award duration: 3 years
Sponsor: British Skin Foundation
Supervisors
Dr. Shoba Amarnath, Biosciences Institute, Newcastle University
Dr. Arian Laurence, University College London Hospitals (External)
Dr. Katie Smith, Biosciences Institute, Newcastle University
Eligibility criteria
You must have, or expect to achieve, at least a first or upper 2:1 honours degree or international equivalent, in biomedical sciences, immunology or cancer biology. The candidate must have or be willing to learn bioinformatics.
This award is available to home and international applicants. Successful international candidates will be required to make up the difference between home fees and international fees.
English Language requirements: IELTS 6.5 overall, with 5.5 or more in each sub-skill.
How to apply
To apply for a studentship, you must register and apply through the University’s Apply to Newcastle Portal
Once registered select ‘Create a Postgraduate Application’.
Use ‘Course Search’ to identify your programme of study:
You will then need to provide the following information in the ‘Further Details’ section:
In addition, you will need to upload the following supporting documentation:
You will not be able to submit your application until you have submitted all required documents/information.
Contact details
For informal enquiries please contact Dr. Shoba Amarnath at shoba.amarnath@newcastle.ac.uk
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