Post-doctoral Scientist, Oxford MND Centre

We are looking for an enthusiastic postdoctoral researcher looking to develop an independent research career is required for a cutting-edge program of research to systematically investigate calcium channel antagonists as a class of drugs with potential for disease modification in amyotrophic lateral sclerosis (ALS). Several members of the class of CCBs will be assessed for phenotypical modification and target engagement across a range of cellular models (an ESC-derived motor neuron model of ALS, iPSC-models based on a number of ALS determining mutations). Specifically, we aim to 1) Establish whether the effect of CCBs (for which we have preliminary evidence) is a class effect, 2) determine the specific targets of calcium channel blockers, which mediate improved survival in our cellular models, 3) in collaboration with colleagues in Edinburgh extend testing to mouse and zebrafish models. The ultimate goal is to select CCBs for prioritization in experimental medicine studies in humans with ALS and to develop drug specific biomarkers for use in these studies.

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