Research Assistant (Fixed Term)

We are seeking an enthusiastic and committed Research Assistant to join our laboratory in the Cambridge Institute for Medical Research (CIMR) to study the genetic basis of pulmonary vascular disease using mouse and cell models. Applicants must have laboratory experience and a degree in biological science. Prior animal experience would be advantageous, though training will be provided. There is the potential to pursue a research degree (MPhil) during this project.

Mutations in GCN2 cause a rare but progressive and ultimately fatal form of pulmonary hypertension called pulmonary veno-occlusive disease. There is currently no licenced drug treatment for this. We are seeking to understand how loss of GCN2 causes pulmonary vascular disease and have developed 2 mouse models in the first instance to dissect out mechanisms of disease.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

Relevant papers:

Bone morphogenetic protein receptor type II deficiency and increased inflammatory cytokine production. A gateway to pulmonary arterial hypertension. (2015) Soon E, Crosby A, Southwood M, et al. Am J Respir Crit Care Med. 2015 Oct 1;192(7):859-72. doi: 10.1164/rccm.201408-1509OC.

The integrated stress response in pulmonary disease. (2020) Emanuelli G, Nassehzadeh-Tabriz N, Morrell NW, Marciniak SJ. Eur Respir Rev. 2020 Oct 1;29(157):200184. doi: 10.1183/16000617.0184-2020.

Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension. (2024) Emanuelli G, Zhu J, Morell NW, Marciniak SJ (2024). bioRxiv. 2024 Jan 30. doi.org/10.1101/2024.01.27.577559.

Please contact Professor Stefan Marciniak (sjm20@cam.ac.uk) or Elaine Soon (eels2@cam.ac.uk) for further information.

Fixed-term: The funds for this post are available for 1 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

To apply online for this vacancy and to view further information about the role, please visit: www.jobs.cam.ac.uk/job/46432

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SC41596 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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