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Postdoctoral Training Fellow - Developmental Dynamics Laboratory

The Francis Crick Institute - Briscoe Laboratory

Location: London
Salary: Competitive with benefits, subject to skills and experience
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 18th January 2019
Closes: 17th February 2019
Job Ref: 9685

Location: The Francis Crick Institute, Midland Road, London         

Contract: Full time, fixed-term (4 years)

A fully funded postdoc position is available for a computational biologist in the Briscoe lab. The post holder will work closely with experimentalists to analyse single cell and bulk genomic and transcriptomic data aimed at understanding the molecular and cellular mechanisms that underpin the development of the vertebrate nervous system.

The Briscoe lab studies how complex tissues of multicellular organisms develop in a precise and reproducible manner. In most tissues signals - termed morphogens - act as positional cues to control cell fate specification by regulating the transcriptional programme of responding cells. The lab investigates how signals are perceived and interpreted by cells by gene regulatory networks using molecular, genomic, imaging and modelling approaches. They develop and apply novel tools and approaches to obtain a comprehensive view of neural tube development and to analyze the interdependence between different aspects of pattern formation. For the experimental studies, a range of models including mouse and chick embryos as well as mouse and human embryonic stem cells are used.

Project Scope

The lab is looking for a creative, proactive and enthusiastic computational biologist to develop and apply methods for the analysis of genomic and transcriptomic data to study the development of the vertebrate nervous system. This is a highly collaborative project, in which the successful candidate will lead analyses working closely with developmental biologists generating novel experimental datasets and interact with other computational biologists in the institute. Experience in the analysis of population and single cell transcriptomic and genomic (ChIP, ATAC…) data is required as well as an interest in developmental biology and gene regulatory networks.

Postdoctoral Training Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research.

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a brand new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; to developing emerging talent and exporting it the rest of the UK; to public engagement; and to helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

The closing date for applications is 17 February 2019 at 23:30 pm.

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