|Salary:||Competitive with benefits, subject to skills and experience|
|Placed On:||18th January 2019|
|Closes:||18th February 2019|
Location: The Francis Crick Institute, Midland Road, London
Contract: Fixed-term, 3 years
We seek a talented and motivated Project Research Scientist in Bioinformatics to join Dr BriGitta Stockinger’s and Dr Vassilis Pachnis’ laboratory. The AhRimmunity (Dr Stockinger) and Development and Homeostasis of the Nervous System (Dr Pachnis) Laboratories study environmental influences on gut homeostasis and the development of the lineages of the enteric nervous system. In addition, the Stockinger and Pachnis laboratories carry out collaborative work to explore the role of neuro-immune interactions in gut physiology and homeostasis. Details of research projects currently being undertaken in the two laboratories can be seen at:
The successful candidate will join the teams lead by BriGitta Stockinger and Vassilis Pachnis at the Francis Crick Institute.
The groups study molecular pathways implicated in immunity, lineage development and neuroimmune interactions using a range of cell culture and in vivo experimental models. The project will include bioinformatics analysis and annotation to develop tools for analysis of RNA sequence data of immune, epithelial, and neural lineages of the gut at different developmental and postnatal stages. Furthermore, we will generate large scale datasets probing the functional response of immune, epithelial and neuronal cells following inflammatory stimuli and cancerogenesis.
This will involve working with other scientists from the groups to analyse large-scale data sets for genomic, RNA-seq, single cell seq data, ChIPseq and ATAC/ATACseq data, proteomic data, mass spectrometry and mass cytometry.
Activities will include quality control and transcription profiling and integration of genomic datasets with public and commercial biomedical data sources for annotation and interpretation: development, maintenance and optimisation of analysis pipelines and procedures. The post holder will make strategic contributions to experimental design and advise colleagues in the group in the analysis of transcriptional data from human disease and experimental models. This will involve assisting scientists with data interpretation, data mining for interesting patterns and signatures in addition to conducting their own analyses.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under one building in Europe.
The Francis Crick Institute is world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it to the rest of the UK; public engagement, and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
Type / Role: