|Salary:||£31,302 to £33,199 Grade 7 per annum|
|Placed On:||26th March 2019|
|Closes:||23rd April 2019|
Contract Type: Fixed-term for 24 months
Applications are invited from outstanding early-career scientists for a Postdoctoral Research Associate post working with Professor Albert Ong (Academic Nephrology Unit) on an exciting project to functionally characterize the transcriptomic and proteomic signatures altered in cellular and experimental models of autosomal dominant polycystic kidney disease (ADPKD), as a first step in developing novel treatments for this major kidney disease.
ADPKD is the most common genetic disease leading to kidney failure in man and is caused by mutations in two major genes, PKD1 and PKD2 and a number of recently identified minor genes (GANAB, DNAJB11). Work in our laboratory has identified key transcriptomic and proteomic signatures of the cystic cellular phenotype and the major aim of this project is to study how these changes relate to the function of the ADPKD proteins, polycystin-1 and polycystin-2.
The post provides an excellent opportunity to undertake high quality research in a stimulating multi-disciplinary context. We are looking for an enthusiastic researcher with a strong background in cell biology, experience of molecular biology and protein biochemistry techniques with relevant skills in bioinformatics. Experience and interest in RNA biology, developmental or stem cell biology would be an advantage. The post would suit an early career researcher who is looking to build on their successful doctoral and/or early-postdoctoral experience to write a competitive career development fellowship application in this field.
You should have a PhD (or equivalent experience) in cell biology, molecular biology or a related discipline.
The post is full-time and fixed-term for 24 months.
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