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Research Fellow

University of Birmingham - Institute of Metabolism and Systems Research - College of Medical and Dental Sciences

Location: Birmingham
Salary: £30,395 to £39,609 With potential progression once in post to £42,036 a year (Grade 7)
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 23rd August 2019
Closes: 22nd September 2019
Job Ref: 80054

Duration Fixed Term Contract to 31 May 2022

We are seeking a talented postdoctoral fellow to join Prof. David Hodson’s research group at the Institute of Metabolism and Systems Research (IMSR), University of Birmingham (http://www.birmingham.ac.uk/staff/profiles/metabolism-systems/hodson-david.aspx). The project, funded by a prestigious European Research Council Starting Grant (“OptoBeta”), seeks to combine transcriptomics with next generation in vivo imaging approaches to identify novel mechanisms underlying insulin release. The overarching aim is to understand the basis for insulin secretory failure during type 2 diabetes, and use this information to produce novel therapies.

The post holder will contribute to research in Dr Hodson’s group using a variety of techniques:

  • PCR, cloning and plasmid generation.
  • Production of adenoviruses and/or lentivirus including amplification and titre to maintain stocks.
  • Assisting with the generation, breeding and maintenance of transgenic (Cre-lox) animal colonies including genotyping.
  • Mouse metabolic phenotyping (IPGTT, ITT, OGTT, body weights).
  • Culture of primary cells (e.g. mouse and human islets) and cell lines (e.g. MIN6,INS1E, 1.1B4):
  • Specific immunoassays for insulin, glucagon, GLP-1 etc.
  • Gene over-expression and gene-silencing (e.g. siRNA, shRNA).
  • Insulin and glucagon secretion assays.
  • ATP/ADP, β-arrestin, Ca2+ and cAMP assays.
  • Isolation of RNA and quantification of gene expression, including for RNASeq and other single cell transcriptomic approaches.

The main responsibilities of the role will include:

  • Analysis and interpretation of data as required.
  • Contribute to and write papers as required.
  • Attendance at conferences as required.
  • Develop research objectives and proposals for own or joint research, with assistance of a mentor if required
  • Contribute to writing bids for research funding
  • Apply knowledge in a way which develops new intellectual understanding
  • Disseminate research findings for publication, research seminars etc
  • Supervise students on research related work and provide guidance to PhD students where appropriate to the discipline
  • Contribute to developing new models, techniques and methods 
  • Undertake management/administration arising from research
  • Contribute to Departmental/School research-related activities and research-related administration

The successful candidate will need to have:

  • First degree in biology, biomedical science, biochemistry or similar with a higher degree in an appropriate subject (e.g. metabolism, diabetes, neuroscience or imaging).
  • High level analytical capability
  • Ability to communicate complex information clearly
  • Fluency in relevant models, techniques or methods and ability to contribute to developing new ones

The closing date for applications is 22 September 2019.

For further information please contact David Hodson D.Hodson@bham.ac.uk  or telephone 0121 414 6896

To download the full job description and details of this position and submit an electronic application online please click on the Apply Online button below or visit www.hr.bham.ac.uk/jobs  Please quote Job Ref 80054 in all enquiries.

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