The University of Cambridge wishes to appoint a postdoctoral scientist to join Dr Julien Prudent's Mitochondrial Physiology research group in the MRC Mitochondrial Biology Unit in Cambridge.
The postholder will work within a programme entitled "Mitochondrial dynamics and inter-organelle contact sites in cell metabolism and death". Mitochondria are highly dynamic organelles constantly adapting their shape through fusion/fission events, to ensure their physiological functions. A critical discovery in the field of mitochondrial cell biology has been the identification of transient and specialized molecular structures connecting mitochondria with other organelles. Numerous inter-organelle contacts have been identified and functionally linked to mitochondrial functions, including cell survival and metabolism.
The goal of the project is to understand the regulations and functions of mitochondrial dynamics and inter-organelle contacts during cell survival/death events, metabolism and inflammation. Developing biochemical, cell biology and advanced microscopy methods, the post-holder will undertake research to study mitochondrial ultrastructure, relationship between inner and outer membrane dynamics and organelle contact sites adaptations during different metabolic states. The associated-mechanisms regulating these morphological transitions will be investigated.
Candidates will have (or be about to be awarded) a PhD in biochemistry, or molecular and cellular biology, and a track record of related research achievements. Knowledge in mitochondrial physiology, including dynamics, contact sites, and strong experience in collection and processing of confocal and/or super-resolution microscopy data, including live cell imaging are essential.
This is a fixed term training programme post for 3 years from date of appointment.
The MRC Mitochondrial Biology Unit is a world-renowned centre for research in respiratory enzymes. Additional information can be found at www.mrc-mbu.cam.ac.uk.
The department require the successful candidates start date to fall between January - February 2020.
To apply online for this vacancy and to view further information about the role, please visit: www.jobs.cam.ac.uk/job/23155
The closing date for applications is Sunday 27th October 2019 with interviews taking place week commencing 18th November 2019.
Please ensure that you upload your Curriculum Vitae (CV) and a covering letter in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager
Please quote reference SM20631 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
|Salary:||£32,816 to £40,322|
|Placed On:||11th September 2019|
|Closes:||27th October 2019|
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