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Research Associate (Fixed Term)

University of Cambridge - Department of Clinical Neurosciences

Location: Cambridge
Salary: £32,816 to £40,322
Hours: Full Time, Part Time
Contract Type: Fixed-Term/Contract
Placed On: 18th October 2019
Closes: 17th November 2019
Job Ref: ZE21133
 

This is an exciting opportunity for a post-doctoral research associate to join the Department of Clinical Neurosciences.  

Project Title - A scaffolding strategy for stimulating opticnerve regeneration 

The project focusses on regeneration of axons in the damaged spinal cord and optic nerve. The group has identified PROTRUDIN as a new and powerful stimulator of axon regeneration. Protrudin is a scaffolding molecule that links several of the key participants in regeneration, (kinesin, transport/trafficking endosomes, endoplasmic reticulum, PIP3 signalling). The molecule is activated by phosphorylation, and a phosphomimetic form of the molecule is a very powerful stimulator of regeneration in cortical neurons and in retinal ganglion cell axons in the crushed optic nerve. 

The purpose of the grant is to test protrudin together with other interventions for stimulating regeneration in the corticospinal tract in the damaged spinal cord and in the visual system damaged by optic nerve crush and glaucoma. The work will also address mechanism, with the aim of learning more about how protrudin stimulates axon growth. A particular focus will be the involvement of endoplasmic reticulum in regeneration. 

Applicants should have experience of in vivo experiments in the rodent nervous system. 

Koseki, H., M. Donega, B.Y. Lam, V. Petrova, S. van Erp, G.S. Yeo, J.C. Kwok, C. Ffrench-Constant, R. Eva, and J.W. Fawcett. 2017. Selective rab11 transport and the intrinsic regenerative ability of CNS axons. Elife. 6:e26956. 

Petrova, V., and R. Eva. 2018. The virtuous cycle of axon growth: Axonal transport of growth-promoting machinery as an intrinsic determinant of axon regeneration. Dev Neurobiol. 10:898-925. 

Fawcett, J.W. 2019. The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult? Neurochem Res. doi: 10.1007/s11064-019-02844-y 

Fixed-term: The funds for this post are available for 30 months in the first instance. 

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check. 

To apply online for this vacancy and to view further information about the role, please visit :

http://www.jobs.cam.ac.uk/job/23690

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. 

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager. 

The closing date for applications is 15 November 2019. 

For further details, please contact James Fawcett (jf108@cam.ac.uk) or Richard Eva (re263@cam.ac.uk). 

Please quote reference ZE21133 on your application and in any correspondence about this vacancy. 

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. 

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

   
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