|Salary:||£32,816 to £40,322|
|Placed On:||18th October 2019|
|Closes:||17th November 2019|
A post-doctoral Research Associate position funded by Wings for Life is available in the James Fawcett and Andras Lakatos group.
Project Title: Novel Regeneration Scaffolding molecule
The project focusses on regeneration of axons in the damaged spinal cord and optic nerve. The group has identified PROTRUDIN as a new and powerful stimulator of axon regeneration. Protrudin is a scaffolding molecule that links several of the key participants in regeneration, (kinesin, transport/trafficking endosomes, endoplasmic reticulum, PIP3 signalling). The molecule is activated by phosphorylation, and a phosphomimetic form of the molecule is a very powerful stimulator of regeneration in cortical neurons and in retinal ganglion cell axons in the crushed optic nerve. The purpose of the grant is to test protrudin together with other interventions for stimulating regeneration in the corticospinal tract in the damaged spinal cord and in the visual system damaged by optic nerve crush and glaucoma. The work will also address mechanism, with the aim of learning more about how protrudin stimulates axon growth. A particular focus will be the involvement of endoplasmic reticulum in regeneration.
Applicants should have experience of in vivo experiments in the rodent nervous system.
Koseki, H., M. Donega, B.Y. Lam, V. Petrova, S. van Erp, G.S. Yeo, J.C. Kwok, C. Ffrench-Constant, R. Eva, and J.W. Fawcett. 2017. Selective rab11 transport and the intrinsic regenerative ability of CNS axons. Elife. 6:e26956.
Petrova, V., and R. Eva. 2018. The virtuous cycle of axon growth: Axonal transport of growth-promoting machinery as an intrinsic determinant of axon regeneration. Dev Neurobiol. 10:898-925.
Fawcett, J.W. 2019. The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult? Neurochem Res. doi: 10.1007/s11064-019-02844-y.
Fixed-term: The funds for this post are available for 2 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.
To apply online for this vacancy and to view further information about the role, please visit:
The closing date is 17 November 2019, with the interview date TBC.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference ZE21136 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
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