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Research Fellow (MRC) (102246-0120)

University of Warwick

Location: Coventry
Salary: £30,942 to £40,322 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 29th January 2020
Closes: 27th February 2020
Job Ref: 1860252
 

Full time, fixed term contract for 2 years.

This might have to be shortened to a maximum of 19 months depending on the starting salary of the successful candidate and subject to the funding being confirmed and transferred to Warwick. The role is 50% split between the Chemistry and School of Life Sciences Departments.

The twin arginine protein transport (Tat) system is a conserved and highly unusual protein transport pathway that exports folded proteins across the cytoplasmic membranes of bacteria. It is required for the virulence of most important human pathogens and is essential for the viability of pathogenic mycobacteria. The Tat system assembles 'on demand' in the presence of a substrate protein and disassembles once transport is completed. The aim of this study is to provide key information about the interaction of Tat substrates with the Tat receptor through a combination of molecular dynamics and modelling, in conjunction with in vivo crosslinking and biochemistry, performed by the lab of Prof Tracy Palmer FRS at the University of Newcastle.

The project has the following specific objectives:

  1. To map the signal peptide binding site within the Tat receptor and to determine whether binding of the signal peptide at this site is dependent on the protonmotive force;
  2. To determine whether the newly-discovered TatA/B binding site on TatC TM6 is essential for operation of the Tat pathway.
  3. To examine the organisation and activation mechanism of the Tat receptor in Tat translocases that lack the TatB component.

We seek to appoint a candidate with working experience in biophysics, biochemistry, chemistry, physics, or similar quantitative discipline. Expertise in computational techniques such as molecular modelling, molecular simulation, and structural bioinformatics is essential, while working knowledge of programming languages, such as python, is highly desirable. Familiarity with the bacterial cell envelope would be highly beneficial.

Informal enquiries can be addressed to Dr Phill Stansfeld (phillip.stansfeld@warwick.ac.uk). Further information about research in the Stansfeld lab can be acquired from the following webpage: https://warwick.ac.uk/fac/sci/lifesci/people/pstansfeld/

Full details of the duties and selection criteria for this role can be found in the vacancy advert on the University of Warwick’s jobs pages. You will be routed to this when you click on the Apply button below.

   
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