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Research Associate

University of Sheffield - Department of Chemistry

Location: Sheffield
Salary: £31,866 to £33,797 per annum (Grade 7)
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 11th March 2020
Closes: 10th April 2020
Job Ref: UOS025671

Contract Type: Fixed term for 3 years to start as soon as possible.

Faculty: Faculty of  Science

We have an exciting opportunity for a biophysicist to work in the Craggs Lab on a multidisciplinary BBSRC-funded project, investigating the role of DNA dynamics in damage recognition. You will use and develop a range of novel single-molecule and ensemble techniques (including FRET, SAXS and SPR) to determine the conformational dynamics of aberrant DNA structures and their effects on nucleosome packing. Whilst this is primarily an experimental project, you will also have the chance to integrate your results into comprehensive molecular dynamics models in collaboration with Professor Lindorff-Larsen (Copenhagen).

You will have a PhD in Biophysics, Physics or a relate subject, preferably with expertise in single-molecule methods and quantitative analysis, with an interest in DNA biophysics. Due to its broad scope you will be able to tailor the project’s development in line with your own career ambitions. We strongly encourage interested candidates to get in touch for more specific information on the project and its scope (email Dr. Tim Craggs). You will need effective communication skills, both written and verbal, report and paper writing skills, and experience of delivering presentations.

You will be part of a multidisciplinary team in a rapidly growing lab, developing a range of novel biophysical methods tackling questions in protein and nucleic acid biology. Key to your growth and success will be the ability to collaborate with a wide range of scientists including physicists, chemists and biologists.

You will be supervised by Dr. Tim Craggs, who has been at the forefront of developing single-molecule FRET methods for dynamic structural biology. His newly refurbished optics lab is part of the Imagine: Imaging Life facility at TUOS, and is well equipped for all the microscopy aspects of the project. For more information on the Craggs Lab see:

Additional expertise and mentorship will be provided by Oleksandr Mykhaylyk and Robert Rambo (SAXS), and David Williams (Nucleic acid chemistry). There will also be opportunities to work with our industrial partners (Cairn Research and Insplorion).

We’re one of the best not-for-profit organisations to work for in the UK. The University’s Total Reward Package includes a competitive salary, a generous Pension Scheme and annual leave entitlement, as well as access to a range of learning and development courses to support your personal and professional development.

We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.

To find out what makes the University of Sheffield a remarkable place to work, watch this short film:, and follow @sheffielduni and @ShefUniJobs on Twitter for more information.

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