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Higher Scientific Officer - Next Generation Sequencing

Institute of Cancer Research - Evolutionary Genomics & Modelling

Location: London, Sutton
Salary: £32,000
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 21st September 2020
Closes: 22nd October 2020

Length of Contract: 27 months

The new Centre for Evolution and Cancer within the Institute of Cancer Research is supported by a Strategic Award from the Wellcome Trust. We focus on interrogating clonal evolution in tumours by studying the dynamics of heterogeneous cancer cell populations and their microenvironment. We make use of multi-region genomic profiling, single-cell genetics, computational histopathological analysis and mathematical modelling to reconstruct the past evolutionary history of tumours and predict their future.

Prof Andrea Sottoriva is the Director of the Centre for Evolution and Cancer and his lab focuses on deciphering the dynamics of cancer growth, progression and treatment resistance in each patient using a combination of cancer genomic approaches, experimental model systems and mathematical analyses, with the objective of predicting the future course of the disease.

For this position, we are seeking a highly motivated Higher Scientific Officer with expertise in cancer genomics and next-generation sequencing. The successful candidate will be responsible for performing nucleic acid extraction, library preparation and sequencing (targeted panels, whole-exome, whole-genome sequencing) on cancer samples from retrospective patient cohorts and clinical trials, with the objective of characterising the evolution of treatment resistance. The candidate will interact with other members of the lab, including computational scientists and bioinformaticians for the analysis of the data. The candidate must have a solid cancer biology background, experience with next-generation sequencing and be highly organized and meticulous. The successful candidate will work closely with a diverse team to formulate and validate hypotheses.

The ICR is the leading academic research centre in the UK. Effective industry collaboration and innovation in new medicines and technologies are at the heart of our approach to drive benefits for patients. The ICR is ranked:

  • first for the quality and impact of our research*
  • second worldwide for the number of our publications cited in patents**
  • fourth worldwide for the citation rate of scientific research published across all fields**
  • fourth worldwide for top-cited research publications**
  • in the top five higher education institutions worldwide for academic influence and commercial impact**

2014 Research Excellence Framework

** U-Multirank, 2020

We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.

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