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Postdoctoral Research Scientist/ Senior Postdoctoral Research Scientist (Signalling)

Babraham Institute

Location: Cambridge
Salary: £32,200 to £46,000 starting salary per annum (depending on experience)
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 16th October 2020
Closes: 15th November 2020

The Babraham Institute is a charity which is world renowned for its research in life sciences to enhance lives and improve wellbeing.

We are seeking an enthusiastic Postdoctoral Research Scientist or Senior Postdoctoral Research Scientist to join Heidi Welch’s group in our Signalling Programme, to study cell signalling through Rac Small GTPases and Rac-GEFs.

Rac family Small GTPases control cytoskeletal dynamics to regulate cellular processes such as adhesion, migration and vesicle trafficking. We study the importance of the activators of Rac, Rac-GEFs, in these processes. Rac-GEFs greatly outnumber Rac GTPases, and we are interested in the diversity of Rac-GEFs, aiming to understand their unique roles in various systems. Currently, we are investigating the roles of P-Rex and other Rac-GEFs in the clearance of bacterial infections, in glucose homeostasis and in receptor trafficking processes. We are also interested in the molecular mechanisms that regulate Rac-GEFs, and we are generating new tools for monitoring Rac-GEF activity, using these to study how Rac-GEFs integrate upstream signals to generate the subcellular patterns of Rac activity that elicit specific cell responses.

This postdoctoral position plays a central role in our research programme, combining methods such as molecular and cell biology, biochemistry, imaging and various models of health and disease, including in vivo animal models. In addition to conducting his/her research in one or more of the areas outlined above, the post holder will help with training the lab’s graduate students and with outreach activities. S/he will benefit from the Institute’s world-leading expertise in signalling, from our excellent research facilities, and from existing external collaborations within the UK and internationally.

The successful candidate must have a PhD in biology, biochemistry or related disciplines, with a demonstrable track record in signalling research. Experience in molecular biology, cell biology, protein biochemistry and imaging techniques is essential. Experience in Small GTPase/GEF biology and with animal models of disease is highly desirable.

The level of which the candidate is employed at will be decided at appointment by the interview panel. Funding for this position is available for three years in the first instance.

Informal enquiries can be made to Dr Heidi Welch:

For more information on the work of the group, please visit:

Applicants must hold a PhD or have their thesis submitted when commencing the post. Please note that you will be appointed on the starting salary of £30,000 per annum, if you have not yet been awarded your PhD.

Interviews for this vacancy are planned in the week starting 7th December 2020.

For further details about this position or to apply online please visit here

Further information about the Institute can also be found on our website (


The Babraham Institute holds a silver Athena SWAN award and is committed to promoting and developing a culture of excellence, diversity and mutual respect that supports the Institute’s ambitions and attracts highly motivated and talented people.

The Babraham Institute is a Disability Confident Employer and has a positive approach to employing disabled people.

The Babraham Institute receives strategic funding from the Biotechnology and Biological Sciences Research Council and is an Equal Opportunities Employer.

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