We have an opportunity for a postdoctoral fellow to join us under the leadership of Dr Ana Cvejic (University of Cambridge) and Peter Campbell (Wellcome Sanger Institute) as part of the Open Targets program.
Open Targets aims to provide evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. This pioneering public-private partnership between Sanofi, Celgene, EMBL-EBI, GlaxoSmithKline, and the Wellcome Sanger Institute, aims to provide a R&D framework that applies to all aspects of human disease, and to share its data openly with the scientific community (http://www.opentargets.org).
About the Role:
In this project, you will analyse newly generated single cell (scRNA-Seq and scATAC-Seq) as well as novel and spatial transcriptomics data sets (In Situ Sequencing and 10x Visium) to understand the molecular properties of immune cells infiltrating tumour sites. The underlying data sets comprise thousands of unique molecular signals measured for tens of thousands of cells or physical locations in each tumour. You will employ methods from high dimensional and spatial statistics, and machine learning, to chart and understand the nature of different tumour-associated immune cells, how they interact and change biological functions and how the underlying molecular changes could be exploited as therapeutic targets.
You will have a PhD in Bioinformatics, Computational Biology, Biostatistics or in a related quantitative field (e.g. Mathematics, Physics, Statistics). You will be passionate about science, hardworking, and excited to learn and improve your skills in an outstanding and supportive research environment. You will be part of a multidisciplinary team and will be tasked with proactively seeking and maintaining appropriate collaborations. You will also be expected to drive forward the project, working closely with biologists, clinicians and bioinformaticians within and outside the group to accomplish scientific objectives.
Behaviours and Competencies:
Please apply with your CV and a cover letter outlining your suitability for the role addressing the criteria set out above and in the job description.About Open Targets
Open Targets is a pioneering public-private partnership between European Bioinformatics Institute (EMBL-EBI), GlaxoSmithKline (GSK), the Wellcome Sanger Institute (Sanger), Sanofi and Bristol Meyers Squibb (BMS), located at the Wellcome Genome Campus in Hinxton, near Cambridge, UK.
Open Targets brings together expertise from five complementary institutions to generate evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. Open Targets aims to provide an R&D framework that applies to all aspects of human disease to improve the success rate of discovering new medicines and share data openly in the interest of accelerating drug discovery.
|Salary:||£32,780 to £41,093 PDF|
|Placed On:||14th September 2021|
|Closes:||8th October 2021|
Type / Role: