|Salary:||£36,382 to £40,927|
|Placed On:||8th October 2021|
|Closes:||4th November 2021|
We have an opportunity for a Research Associate to make a leading contribution to the project ‘Mitochondrial redox protein quality control in ageing’, working with PI Professor Kostas Tokatlidis and in collaboration with the Co-I Prof Alberto Sanz at the IMCSB/MVLS.
Specifically, the postholder will conduct, manage and publish research in the area of mitochondria biology with the aim to elucidate the redox protein quality control processes in mitochondria and how they impact the ageing process.
This knowledge is missing and is a prerequisite to fully understand how mitochondria can maintain a healthy redox balance that is critical for cell survival and stress resistance. This requires a knowledge of both oxidative and reductive pathways and an interplay of these with mitochondrial ROS (mtROS) to preserve mitochondrial fitness in response to deleterious stresses and metabolic alterations. The specific objectives of the project are (1) to dissect the reductive machinery operating in the IMS and analyse its effects on folded protein retention in the IMS or retrograde export and degradation (2) to dissect the effects of the redox machinery on the global IMS redox state and mitochondrial metabolite transport in signalling processes (3) to investigate the redox protein quality control as a key determinant in organismal ageing using Drosophila. The postholder will also assist in managing, directing and developing this complex and challenging project.
This post is full time and fixed term until 31st January 2025.
Informal enquiries should be directed to Professor Kostas Tokatlidis via email: Kostas.Tokatlidis@glasgow.ac.uk
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The University of Glasgow, charity number SC004401.
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