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Senior Drug Discovery Scientist (Structural Biology / Biophysics)

University of Dundee

Within the University of Dundee, the newly announced Centre for Targeted Protein Degradation (CeTPD) is being created as a first of its kind Centre leading a number of internationally significant projects in the burgeoning new area of translational chemical biology and targeted protein degradation. The goal of CeTPD is to innovate the next-generation of small-molecule platforms and modalities to advance chemical and biological insights and therapeutic targets related to human diseases. It aspires to achieve this by openly collaborating with academic, industrial and venture partners, and by training and inspiring the next-generation of research scientists and leaders.

We are seeking to appoint a Senior Scientist to join our expanding group based at the University of Dundee in the new Centre for Targeted Protein Degradation (CeTPD), due to open in early 2022. The focus of this new role will be to drive and accelerate degrader drug discovery projects within a multi-disciplinary drug discovery team engaged in structure based PROTAC design in an exciting collaboration between the University of Dundee and Boehringer Ingelheim. The joint team’s mission is to discover novel small-molecule degraders to treat cancers with serious unmet medical needs. There is significant scope for the successful candidate to develop and augment discipline-based activities to support the on-going discovery efforts of this collaboration team, as well as of the wider CeTPD group.

Your priorities will include:

  • Accountable for whole multi-disciplinary project performance and delivery in line with collaboration objectives, including meeting key project and financial milestones.
  • Use a depth and breadth of biophysical assay development and structural determination experience and knowledge to provide creative solutions that will drive projects forward.
  • Lead the preparation and presentation of project updates/reviews to both collaboration joint steering committee and collaborator internal research portfolio committee meetings.
  • Significantly contribute to the quality and delivery of mentorship and training of junior medicinal chemists across the CeTPD.
  • Lead implementation of best practices within own discipline across all CeTPD teams.

Who we’re looking for:

  • Ph.D in structural biology or a related discipline OR a degree in chemistry or biology with additional relevant experience in industry.
  • Significant experience as a senior member of drug discovery projects, defining team strategy.
  • Track record of intellectually and practically driving the characterization of ligand:protein interactions to push forward drug discovery projects.
  • Demonstrated high level performance in scientific leadership, communication and strategy to deliver project goals.
  • Experience in using state-of-the-art structural determination techniques which may include x-ray, Cryo-EM , ,NMR and/or HDX-MS.

We are one of the UK’s leading universities – internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city-centre campus is at the heart of Dundee - an up-and-coming, friendly, compact and affordable city with a rich heritage in design and technology. Just a short walk from the V&A Museum of Design Dundee, we’re close to both the train and bus stations. We also have campuses at Ninewells Hospital and in Kirkcaldy which are easily accessible via local transport links.

The University of Dundee is a signatory of the Researcher Development Concordat and is committed to enhancing the research environment and culture. Engagement and support of activities which assist the researcher development agenda at the University is therefore essential.

For further information about this position please contact Professor Alessio Ciulli at

The closing date for applications 7th November 2021 (Midnight UK Time).

The University of Dundee and the School of Life Science hold an Athena SWAN Silver Award, which recognises the promotion of gender equality. We strongly believe that diversity in our staff is crucial for our creativity and success and are committed to advance our inclusive culture by supporting and encouraging all staff and provide bespoke support as required for under-represented groups.
Location: Dundee
Salary: £42,149 to £50,296 Grade 8
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 8th October 2021
Closes: 7th November 2021
Job Ref: SLSC0956
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