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Senior/Laboratory Research Scientist in Glycoproteomics

The Francis Crick Institute

Location: London
Salary: £28,150 to £42,250
Hours: Full Time
Contract Type: Permanent
Placed On: 1st November 2021
Closes: 31st December 2021
Job Ref: R496
 

Short summary

We are looking for an enthusiastic Senior Laboratory Research Scientist in mass spectrometry (MS) glycoproteomics at the Francis Crick Institute. The post is joint between the Chemical Glycobiology Laboratory and the Proteomics Science Technology Platform, combining cutting-edge technology with fundamental questions in glycobiology. We use chemical “precision tools” to chemically tag particular glycans in the living cell, and bioorthogonal chemistry to identify glycosylation sites by tandem MS. We are looking for a team member to spearhead the application of novel reagents and enrichment methods in chemical glycoproteomics experiments at the forefront of glycobiology. This post is particularly well-suited for applicants with a background in MS-glycoproteomics who aim to expand their expertise and contribute to the use of chemical precision tools in a world-class environment of biomedical research.

Key responsibilities

These include but not limited to:

  • Method development to apply novel chemical tools in MS-glycoproteomics, for instance on a brand-new Orbitrap Eclipse (Thermo).
  • Development of procedures for enrichment and sample preparation.
  • Instrument handling and development of ETD-based fragmentation techniques.
  • Data analysis (e.g. by Byonic) and manual validation of spectra.
  • Application of new methods to projects at the forefront of chemical glycobiology, for instance to profile the protein substrate specificities of glycosyltransferases.
  • Co-supervision and mentoring of students in methods of MS-glycoproteomics.
  • Providing guidance on instruments, data interpretation, troubleshooting and other day-to-day activities in the lab to students and other staff members
  • Ensuring that lab records and experimental procedures are well-curated.
  • Contribution to project design.
  • Actively contributing to a positive and stimulating lab atmosphere.
  • Partaking in writing and submission of publications.
  • Presenting own research on national and international platforms where appropriate.
  • Engaging in promoting the lab’s research

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

  • If you are interested in applying for this role, please apply via our website.
  • The closing date for applications is 12 November 2021.
  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
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