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Higher Scientific Officer

The Institute of Cancer Research - Dr. Bruna Lab

Location: Sutton
Salary: £32,000 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 25th November 2021
Closes: 12th December 2021
Job Ref: ID:24

Duration of Contract: Fixed Term for 18 months to start with.

We have an opportunity for a Higher Scientific Officer (HSO) to oversee and provide technical support to the Bruna lab. The post-holder will excel in coordinating the preclinical modelling of paediatric cancer evolution lab. The candidate will also be heavily involved in supporting the development of new single cell tracing techniques of interest to the research team and functional screening approaches. You will also be involved in preclinical work involving patient derived tumour models from difficult-to-treat paediatric cancers. You will closely interact and support other researchers within the group as well as internal and external collaborative efforts, including those within ICR state-of-the-art core facilities, assisting and overseeing a highly collaborative framework in paediatric preclinical modelling. You are expected to participate in the day-to-day running of the laboratory, including ordering supplies, maintaining inventories.

Applicants must have a degree in Biochemistry, Molecular Biology or Cell Biology and in-depth technical laboratory experience in data management, molecular biology and cell biology including cell lines. Experience on genomics, especially library preparation, together with knowledge and ability to perform standard laboratory techniques are desirable. Knowledge of cancer biology, 2-D and 3-D cell culture and cell viability assay methodologies, and familiarity with contemporary approaches to the generation of genetic modifications, such as the use of CRISPR, would also be advantageous.

The position will be offered initially on a fixed-term contract of 18 months. The full salary scale for the post is £32,000 to £44,400 p.a. inclusive. Starting salary expected to be £32,000 but the relevance of skills and previous experience will be taken into consideration.

Preclinical Modelling of Paediatric Cancer Evolution | Centre for Paediatric Oncology Experimental Medicine| Centre for Cancer Evolution: Molecular Pathology Division

The Preclinical Modelling of Paediatric Cancer Evolution team led by Dr. Alejandra Bruna is interested in studying the molecular mechanisms underlying paediatric cancer evolutionary processes leading to therapy resistance and relapse. Our goal is to develop a preclinical framework to help identify more efficient and less toxic therapeutic strategies for children with cancer. We aim to use patient-derived in vivo and ex vivo improved preclinical tools to increase our understanding of the biology of the disease and the mechanisms underlying the diversity of drug responses. The group is also interested in studying the molecular mechanisms underlying paediatric cancer evolutionary processes to anticipate and therapeutically challenge the unfortunately too often inefficient drug responses seen in the clinic. We take genomic and functional approaches, including those at single cell resolution, to delineate molecular mechanisms underlying cellular and clonal dynamics and how these interplay with treatment responses and in cancer evolutionary processes, including relapse of the primary solid malignancy.

We encourage all applicants to access the job pack on our site for more detailed information regarding this role. 

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