|Salary:||From £38,300 per annum, subject to skills and experience|
|Placed On:||25th November 2021|
|Closes:||22nd December 2021|
Location: The Francis Crick Institute, Midland Road, London
Contract: Fixed Term (3 years), Full time
Salary: From £38,300 per annum, subject to skills and experience
Vacancy ID: R524
This position is to work on an exciting international collaboration funded by Wellcome LEAP to understand how the tumour microenvironment (TME) drives malignant cell states in glioblastoma (GBM). The project will generate and integrate single cell transcriptomics, epigenomics and spatial RNA/DNA-sequencing to systematically dissect TME-GBM cell interactions and plasticity in situ. This will involve the use of large-scale spatial multi-omics approaches. For our component of the collaboration, TME cell interactions and immune phenotypes will be analysed in GBM tissue samples by developing imaging mass cytometry methods. In addition, we will use our expertise and track record in developmental biology to investigate the relationship between the cell states documented in GBM and those in the developing human brain, identifying the embryonic programmes co-opted by malignant cells. The goal is to identify to TME-GBM interactions and malignant cell trajectories.
Key experience and competencies
You will develop imaging mass cytometry methods to assay cellular interactions in GBM, and you will drive data interpretation and design for validation and functional follow-up. In collaboration with others working on the project, you will be responsible for the biological interpretation of integrated single cell and spatial ‘omic datasets, this will involve working closely with computational scientists. You will develop follow-up projects for further validation and functional studies. This might involve patient-derived cell lines, high content screens etc using technologies available through our group and our collaborators.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
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