|Salary:||£38,300 subject to skills and experience|
|Placed On:||22nd December 2021|
|Closes:||20th February 2022|
2 Wellcome Trust funded postdoctoral research posts (immunology and computational biology) in the laboratory of Moritz Treeck (www.treecklab.org) are available. We are looking for curious researchers to investigate the complex interaction of effector proteins that one of the most successful parasite, Toxoplasma gondii, injects into its host cells. Novel single-cell sequencing methods that combine CRISPR screens in the parasite and analysis of transcriptional responses in host cells will be employed to map all Toxoplasma effector proteins that alter host cell behaviour in various hosts and cell types. The function of the effector proteins will be studied in cell culture and in vivo to investigate how effector proteins injected into a host cell can lead to systemic changes of the immune response. This project will appeal to those with an interest in the cell biology and innate immunology of host-pathogen interaction and the complex analysis of single cell sequencing datasets. Extensive collaborations with immunology and cell biology groups within the Francis Crick institute, and co-supervision of the computational work by Prof. Manfred Claassen using machine learning approaches provides a stimulating and diverse framework.
To perform this work, we are looking for 2 motivated postdocs with a strong interest in infection biology and host-pathogen interaction. We are particularly interested in hearing from candidates with a background in either of the following:
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
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