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Research Fellow

UCL - Cancer Institute, Department of Haematology

Location: London
Salary: £36,770 to £44,388 UCL Grade 7, per annum, inclusive of London Allowance
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 7th January 2022
Closes: 2nd February 2022
Job Ref: 1881249
 

The post-holder will carry out high quality discovery research, under the direction of the Principal Investigator, to combine single cell sequencing with flow cytometry and whole-mount confocal microscopy.

The successful candidate will need to prepare results for publication and draft manuscripts, as well as clearly communicate and present results internally and externally to UCL. They will need to perform standard immunology in vivo and ex vivo experiments, including use of microscopy and flow cytometry. The post holder will be working with Stephen Henderson, the co-applicant on this project, to generate and analyse single cell RNA sequencing data.

A creative and professional approach will be needed, when discussing and presenting data and hypotheses in lab meetings, internal seminars and external conferences. The post holder will also need to recognise that research is a team endeavour and engage willingly and effectively with colleagues at UCL, external collaborators and other scientists in the group.

A post-doc position is available to investigate the cell fate signals that determine the differentiation of monocytes in the skin, and how this is altered by disease in the Bennett lab (@BennettlabUCL) at the UCL Cancer Institute (https://www.ucl.ac.uk/cancer/).  

The UCL Cancer Institute is the hub for cancer research at University College London, one of the World’s leading universities. The Institute draws together over 300 talented scientists who are working together to translate research discoveries into developing better, more effective treatments to improve outcomes for cancer patients.  

The Bennett lab also has strong links with the Institute of Immunity and Transplantation at UCL and the Francis Crick institute.  This intersection between world-leading cancer biologists, immunologists and immunotherapists provides an exciting and stimulating working environment.

The skin is an immunological barrier to the external environment and within this barrier, a network of epidermal Langerhans cells (LC) is established before birth and maintained as a self-contained quiescent population of cells throughout life.  However, diseases such as graft - versus - host disease, in which pathogenic T cells destroy resident LC, disturb this status quo and force replacement of LC by new adult bone marrow-derived cells. We have recently discovered that killing of LC leads to the replenishment of the LC network by monocyte-derived cells (doi: 10.1126/sciimmunol.aax8704). But single cell analysis has demonstrated unexpected heterogeneity between epidermal monocytes.  We now seek to determine the cellular mechanisms by which some monocytes succeed in becoming long-lived LC, despite the diseased environment. 

The post-holder will carry out high quality discovery research under the direction of the Principal Investigator, to combine single cell sequencing analysis with flow cytometry, cell culture and confocal microscopy. 

A creative and professional approach will be needed, when discussing and presenting data and hypotheses in lab meetings, internal seminars and external conferences. The post-holder will also need to recognise that research is a team endeavour and engage willingly and effectively with colleagues at UCL, with external colleagues and other scientists in the group. 

This position is funded until the 31st of August 2023 in the first instance with the possibility for extension, and is ideal for a motivated post-doctoral research or someone about to submit their thesis

For enquiries regarding the application process please contact Cancer Institute HR Office ci.hr-office@ucl.ac.uk.

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