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Scientific Officer - Assay Development and Compound Profiling (ID:78)

The Institute of Cancer Research - Cancer Therapeutics

Location: London
Salary: £26,000 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 13th January 2022
Closes: 31st January 2022
Job Ref: ID:78

Key Information

Salary: Starting salary c£26,000

Salary range £26,000 to £33,600 per annum. Appointments are normally made at the starting salary. Future progression is based on annual performance review.

Duration of Contract: Fixed Term for 2 years.

Hours per week: 35 hours per week (Full Time)

Job Details

Summary of Role 

A Scientific Officer position is now available in the Hit Discovery and Structural Design Team within the CRUK Cancer Therapeutics Unit at the Institute of Cancer Research. The team uses biochemical, cellular and biophysical assays to perform small molecule high-throughput screening and compound profiling, coupled with X-ray crystallography to enable structure-based drug design within the Unit. These methodologies are underpinned by state-of-the art protein expression, purification and characterisation capabilities, allowing for the generation of large quantities of high quality protein targets. 

We are seeking an enthusiastic scientist with technical expertise to support assay development and compound profiling activities directed to molecular targets involved in cancer development in our drug discovery portfolio. The successful candidate will develop and run plate-based cellular and/or biochemical screening methodologies to support the identification and characterisation of small-molecule inhibitor’s using a variety of detection technologies. The successful candidate will be an integral member of a multidisciplinary project team and will interact closely with the biologists, computational chemists, medicinal chemists and structural biologists.

Key Requirements

Applicants must have a degree in Biochemistry, or related biological subject and demonstrable technical laboratory experience, including mammalian tissue culture, in a research setting. Knowledge of cancer biology and familiarity with contemporary approaches to drug discovery would be advantageous.

Department/Directorate Information

The Cancer Research UK Cancer Therapeutics Unit, within the Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around 200 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. The Cancer Therapeutics Unit’s exciting goal is to discover high quality drug candidates for validated biological targets and to progress these candidates to clinical trial. All the scientific disciplines are in place to make this possible. Our biologists work alongside world-class chemists and drug metabolism specialists focusing on new molecular targets emerging from human genome and ground breaking cell biology research. This is an exciting and fast moving area of cancer research, and offers the opportunity to work within a multi-disciplinary environment using state-of-the-art techniques and equipment. 

We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Dr Rosemary Burke via Email rosemary.burke@icr.ac.uk.

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