|Salary:||£41,593 to £43,376 per annum|
|Placed On:||14th January 2022|
|Closes:||3rd February 2022|
Location: Hammersmith Campus
Our goals are to improve fundamental understanding of how genetic variation affects the course and neuropathological features of neurological disorders, to learn about underlying molecular mechanisms, and to make use of our insights to improve the diagnosis, prevention and treatment of disease. The primary aim of the project is to explore the relationship between gene variants, neuropathology and pathogenetic mechanisms in Multiple Sclerosis (MS) and Parkinson’s Disease (PD) using post-mortem brain tissues collected at Imperial College. The post holder will use GWAS SNP array genomic data recently generated on 1000 brains to identify individual gene variants that associate with the degree of neurodegenerative and inflammatory pathology in MS and PD. The role of the post holder will be to generate quantitative cellular and molecular neuropathology data using immunohistochemistry and immunofluorescence followed by digital image analysis and to correlate the data with clinical outcomes and presence of individual GWAS variants. They will then go on to analyse both protein and gene expression data for genes and pathways of interest, using a variety of techniques, in order to provide mechanistic insight that can be taken forward into experimental studies.
Duties and responsibilities
This is a Full Time and Fixed Term post for 2 years based at the Hammersmith Campus, London.
Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,694 - £39,888 per annum.
Should you require any further details on the role please contact: Richard Reynolds at firstname.lastname@example.org
Closing date: 3 February 2022
To apply, visit www.imperial.ac.uk/jobs and search by the job reference MED02800
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