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Research Associate

Imperial College London

Location: London
Salary: £41,593 to £43,376 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 14th January 2022
Closes: 3rd February 2022
Job Ref: MED02800
 

Location: Hammersmith Campus

Job Summary

Our goals are to improve fundamental understanding of how genetic variation affects the course and neuropathological features of neurological disorders, to learn about underlying molecular mechanisms, and to make use of our insights to improve the diagnosis, prevention and treatment of disease. The primary aim of the project is to explore the relationship between gene variants, neuropathology and pathogenetic mechanisms in Multiple Sclerosis (MS) and Parkinson’s Disease (PD) using post-mortem brain tissues collected at Imperial College. The post holder will use GWAS SNP array genomic data recently generated on 1000 brains to identify individual gene variants that associate with the degree of neurodegenerative and inflammatory pathology in MS and PD. The role of the post holder will be to generate quantitative cellular and molecular neuropathology data using immunohistochemistry and immunofluorescence followed by digital image analysis and to correlate the data with clinical outcomes and presence of individual GWAS variants. They will then go on to analyse both protein and gene expression data for genes and pathways of interest, using a variety of techniques, in order to provide mechanistic insight that can be taken forward into experimental studies. 

Duties and responsibilities

  • To take initiatives in the planning of research
  • To conduct data analysis
  • To ensure the validity and reliability of data at all times
  • To maintain accurate and complete records of all findings
  • To write reports for submission to research sponsors
  • To present findings to colleagues and at conferences
  • To submit publications to refereed journals
  • To provide guidance to staff and students
  • To attend relevant workshops and conferences as necessary
  • To develop contacts and research collaborations within the College and the wider community
  • To promote the reputation of the Group, the Department and the College
  • To provide guidance to PhD Students
  • To conduct and plan own scientific work with appropriate supervision.
  • To maintain highly organised and accurate record of experimental Work.
  • To actively participate in the research programme of the Group and Unit
  • To publish in high quality journals and to present data at national and international meetings

Essential requirements

  • Research Associate: Hold a PhD (or equivalent) in Neuroscience or a closely related discipline
  • Research Assistant: Near completion of a PhD (or equivalent) in Neuroscience or a closely related discipline
  • Knowledge of immunohistochemistry and image analysis protocols
  • Knowledge of research methods and statistical procedures

Further Information

This is a Full Time and Fixed Term post for 2 years based at the Hammersmith Campus, London.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,694 - £39,888 per annum.

Should you require any further details on the role please contact: Richard Reynolds at r.reynolds@imperial.ac.uk

Closing date: 3 February 2022

To apply, visit www.imperial.ac.uk/jobs and search by the job reference MED02800

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