Back to search results

PhD Studentship Face off , Dissecting the role of phase separation in viral replication and antiviral responses

University of Surrey - Biosciences and Medicine

Qualification Type: PhD
Location: Guildford
Funding for: UK Students
Funding amount: From £15,609 UKRI standard stipend rate (for 2021/22) per annum for 3.5 years
Hours: Full Time
Placed On: 13th May 2022
Closes: 6th June 2022

Background

The assembly of membraneless organelles is emerging as a fundamental paradigm for many cellular functions. Among these, stress granules (SGs) play a central role in health and disease by concentrating proteins and RNAs, driving adaption to stressful conditions, including viral infection. SGs can be either cytoprotective or pro-death, anti-viral or pro-viral. SGs are proposed to act as part of larger coordinated waves of biocondensates assembly in the nucleus – paraspeckles which impact on splicing, and interact with cytoplasmic P-bodies involved in RNA decay. Despite this, the role of biocondensates in infection remains poorly understood. Because SGs and paraspeckles can have anti-viral functions, or promote replication, viruses provide a unique model to elucidate biocondensate functions. At Surrey, Professor Locker has already made fundamental advances in understanding SG function. With its nuclear replication and Professor West’s work at Sussex showing it repurposes cellular RNA binding proteins to regulate gene expression, Epstein-Barr Virus (EBV) provides an excellent to dissect the role of biocondensates during viral infection. 

Objectives

To understand how biocondensates contribute to EBV infection you will: 

  1. Characterise the distinguishing features of biocondensates present in EBV-infected cells, their structures, kinetics and interactions (fixed, live and high-resolution imaging).
  2. Establish how do biocondensates contribute to and manipulate host responses to EBV infection and viral replication (biochemical approaches, cell-based assays)
  3. Develop novel approaches to study the composition of biocondensates in the physiologically relevant context of EBV-infected tumour cells (particles sorting, omics approaches).

Determining how biocondensates direct specialised functions will establish new rules governing host responses to infection. This improved understanding of the role of phase separation during viral infection could inform novel therapeutic approaches.

Supervisory team

This is a collaborative project between the Universities of Surrey and Sussex. Nicolas Locker is a Professor of Virology at Surrey with interests at the interface between RNA biology and virology. His work focuses on understanding how viruses manipulates cellular stress responses during infection to favour replication. At Sussex, Michelle West is a Professor of Tumour Virology with over 20 yrs of experience in dissecting the molecular virology of Epstein Barr Virus, and exploring the interface between cancer biology and virology. She will provide expertise in the viral and cellular models required for this project, and access to outstanding imaging facilities at Sussex. 

Starting in October 2022.

Entry requirements

Open to UK students.

A good honours degree (upper second) in an appropriate discipline. See our PhD programme page for details.

How to apply

Apply via the Biosciences and Medicine PhD programme page.

Please clearly state the studentship title and supervisor on your application.

Funding

The studentship includes: UKRI standard stipend rate (£15,609 for 2021/22) per annum for 3.5 years, coverage of standard home student fees, research fees of £27,140 to support consumables, access charges and travel for the PhD student. Funding for 3.5 years. Funded by the University of Surrey Doctoral Training Programme in Pathogens and Host Defenses.

Application deadline

Monday 6 June 2022

Enquiries

Contact Nicolas Locker (n.locker@surrey.ac.uk).

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

PhD tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
 
More PhDs from University of Surrey

Show all PhDs for this organisation …

More PhDs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge