|Salary:||From £40,125 per annum, subject to skills and experience|
|Placed On:||1st July 2022|
|Expires:||30th August 2022|
Location: The Francis Crick Institute, Midland Road, London
The purpose of this role is to follow up on some exciting recent unpublished results where we have been dissecting the function of TGF-b family signalling in breast and pancreatic cancer. The ultimate aim of this work is to discover how best to target these signalling pathways for therapeutic ends and to determine how to combine anti-TGF-b family signalling therapies with other cancer therapies. We have discovered that manipulation of either the SMAD2/3-dependent or SMAD1/5-dependent TGF-b family signalling pathways strongly impacts the tumour immune microenvironment in both breast and pancreatic cancer. We now want to dissect this in detail, elucidate the underlying mechanisms and determine how we can harness these effects for therapeutic ends.
The project will involve working with mouse models of breast and pancreatic cancer (genetically engineered and orthotopic transplantation models), immunophenotyping, tumour staining and imaging. It may also involve collection and analysis of human samples.
Postdoctoral Training Fellows lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential.
Key experience and competencies
The post holder should embody and demonstrate our core Crick values:
Bold; Imaginative; Open; Dynamic; Collegial
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
Type / Role: