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Research Assistant Neuronal Cell Biologist

University of Oxford - Department of Physiology, Anatomy and Genetics

Location: Oxford
Salary: £29,614 to £35,326 per annum, Grade 6
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 5th August 2022
Closes: 1st September 2022
Job Ref: 159788

Fixed term/Full-time post until 7th June 2023

Applications are invited for a Research Assistant neuronal cell biologist post to work on a collaborative research project between the Oxford Parkinson's Disease Centre (OPDC) and the Oxford Drug Discovery Institute (ODDI) funded by Bristol Myers Squibb (BMS) to perform target and drug discovery for Parkinson’s disease (PD) in the ubiquitination system.

This is an exciting opportunity to work at the interface between academic research and pharmaceutical target and drug discovery to contribute to the discovery of novel therapeutics for PD focused on the ubiquitination pathway. This project aims to better understand the molecular mechanisms around the ubiquitination pathway in PD and develop new therapies by working with induced pluripotent stem cell (iPSC) lines and dopamine neurons generated from PD patients, and cell lines.

Duties will include undertaking laboratory experiments; interpretation of data; imaging analysis; generation and study of iPSC-derived neurons and cell lines; preparation of data for publication; study the mechanisms of action of modulators of the ubiquitination pathway in cellular models of Parkinson’s; contribute to wider project planning and determine the most appropriate methodologies to test hypotheses. You will have excellent practical experience of working with cell cultures and good knowledge of cellular models of neurodegenerative disease. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is essential.

Applicants must hold, or be near completion of, a BSc/MSc in a relevant area of research and have experience in cellular neuroscience, and molecular cell biology relevant to analysis of neuronal phenotypes.

The post is available immediately and is funded until 7th June 2023. The post-holder will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford.

Informal enquiries may be directed Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk).

Closing date for applications is midday on Thursday 1st September 2022

Interviews are likely to be held on Monday 12th September 2022.

While this is a full-time role, we welcome applications from individuals who wish to be considered for flexible working arrangements.

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.

We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion

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