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Mathematical modelling of herpes simplex virus transmission in 2- and 3- dimensions

University of Surrey - Biosciences and Medicine PhD

Qualification Type: PhD
Location: Guildford
Funding for: UK Students
Funding amount: £19,062 per annum for 2022-23, with annual increments based on inflation) and fees covered. Funding also includes a research training and support grant of £3000 for the duration of the studentship. Funding is for 3.5 years.
Hours: Full Time
Placed On: 22nd September 2022
Closes: 18th November 2022

This is an exciting opportunity to undertake an EPSRC-funded PhD that will combine experimental work with mathematical modelling to describe the transmission of the human pathogen herpes simplex virus (HSV) in human cells and tissue models, and develop a comprehensive tool for assessing the parameters that influence virus transmission.

HSV is the causative agent of cold sores, genital herpes, and a range of serious diseases such as keratitis, encephalitis and neonatal herpes. It transmits between cells in one of two ways – cell-free virus or direct cell-to-cell transmission - but the relative contribution in the host is not known. In the lab, transmission of HSV spread is measured by plaque formation on 2D cell monolayers, and can be assessed in the 3D structure of the host tissue using model systems.

This project will combine experimental data of virus replication and spread with mathematical modelling that takes into account a wide range of parameters and will be jointly supervised by experts in herpes virology (Elliott) and mathematical modelling (Rocco). The student will split their time between lab work where they will be trained in tissue culture, virology and advanced imaging techniques, and computational work, where the modelling approach will rely on the construction of dedicated ordinary differential equations models in the first instance, and agent-based models at later stages.

The goal of this project is to develop a comprehensive modelling tool describing viral infection in different scenarios, dependent on experimentally determined parameter values, and accounting for possible therapeutic interventions.

Whilst experience in virology and tissue culture will be an advantage, any highly motivated individual with a keen interest in developing their research in the mathematical biology of virus infection is encouraged to apply. Applicants must have at least a 2:1 degree in a relevant subject and an A-level in Maths.

This is a joint project between virology based in the Dept of Microbial Sciences, and mathematical modelling based in the Dept of Physics.

Supervisors: Professor Gill Elliott, Dr Andrea Rocco

Entry Requirements

Open to UK candidates starting in January 2023.

Applicants are expected to have a good honours degree (first or upper second) or a masters degree in an appropriate discipline, and an A-level in Maths.

IELTS Academic: 6.5 or above (or equivalent) with 6 in each individual category

How to apply

Applications should be submitted via the Biosciences and Medicine PhD programme page. Please clearly state the studentship title and supervisor on your application. Once you have completed and submitted your application, please send an email to the primary supervisors confirming you have applied.

Funding

Enhanced EPSRC stipend (£19,062 per annum for 2022-23, with annual increments based on inflation) and fees covered. Funding also includes a research training and support grant of £3000 for the duration of the studentship. Funding is for 3.5 years. Funded by the EPSRC Doctoral Training Partnership.

Application deadline

18 November 2022

Enquiries

Contact Gill Elliott (g.elliott@surrey.ac.uk).

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