|Salary:||£38,194 to £41,388 per annum|
|Placed On:||23rd September 2022|
|Closes:||12th October 2022|
The advertised position will be working in Dr Mohamed Shamji’s research group within National Heart and Lung Institute (NHLI), Inflammation Repair and Development, Allergy and Clinical Immunology, Faculty of Medicine. Allergic rhinitis (AR) affects up to 40% of the global population and pose a huge economic and social burden. Whilst AR can be controlled temporarily with symptom-reliever such as antihistamines and corticosteroids, a small proportion of sufferers do not respond to treatment. Allergen-specific immunotherapy (AIT) is indicated in these patients. Despite their efficacy, AIT is associated with long-term treatment regimen which is associated with low patient compliance and also occasional severe reactions.
The post-holder will be involved in a very exciting and fast-paced clinical trial study, in collaboration with Revolo Biotherapeutics, to investigate the immunomodulatory properties of a novel peptide that can be used the treatment of allergic rhinitis in AIT. The post-holder will be involved in the collection of clinical samples at multiple timepoints during the clinical trial study and will be involved in performing all relevant immunological and cellular assays to allow assessment of the efficacy of treatment. This will include biobanking of peripheral blood mononuclear cells (PBMCs), basophil activation and histamine release assessment using flow cytometry and in vitro cell culture assays. Flexible attitude towards work is hugely required in this role due to the nature of clinical sample timepoints for the study. The overarching objective is to define the mechanism of action of the novel AIT product and its efficacy.
Duties and responsibilities
Under the direction of the line manager, you will be involved in:
The role will also involve other duties that include:
This is a Full Time and Fixed Term post for 6 months initially based at the South Kensington Campus, London.
Closing date: 12 Oct 22
To apply, visit www.imperial.ac.uk/jobs and search by the job reference MED03399
Type / Role: