Back to search results

PhD Studentship: Secrets of Secretion: The Role of Klu-targets in Entero-endocrine Cell Differentiation in Flies and Humans

University of Kent - Bioscience

Qualification Type: PhD
Location: Canterbury
Funding for: UK Students, EU Students, International Students
Funding amount: From £15,609 doctoral stipend, (2021/2022 rate) per annum
Hours: Full Time
Placed On: 21st October 2022
Closes: 30th December 2022

Supervisor: Dr Jerome Korzelius

j.korzelius@kent.ac.uk

https://www.kent.ac.uk/biosciences/people/3191/korzelius-jerome

About this project:

The entero-endocrine cells of the gut make up the largest endocrine organ. The hormones produced by these cells play a pivotal role in the overall regulation of organism physiology.

Dysregulation of hormone signaling leads to obesity and diabetes, two of the most prevalent and costly chronic diseases in the UK. Our lab was recently awarded an AMS/Wellcome Trust Springboard Award to tackle how entero-endocrine cells differentiate, and how the differentiation of these cells is affected with age differentiation (Korzelius et al., 2019 Nature Communications, Tauc et al., 2021 Elife). In this project, we will use both the fruit fly intestine as well as human intestinal organoids to identify novel regulators of entero-endocrine differentiation.

This PhD project will investigate how EE differentiation is regulated in flies and humans and will focus on finding novel, conserved regulators of EE cell fate. This project will allow you to build skills working with both flies and 3D-organoid culture as well as building skills in genetics, molecular biology and image analysis. We will e.g. perform crosses with inducible expression of RNAi’s, lifespan assays, microdissection and staining of gut tissue and FACS-isolation of midgut cell populations for whole genome RNA-sequencing.

You will work in the dynamic environment of the School of Biosciences at the University of Kent. The School of Biosciences has a rich expertise on Cancer and Ageing research, and we will have close connections to the ageing-related research in the labs of Dr. Jennifer Tullet and Dr. Marina Ezcurra. You will also be able to work with our collaborators at the Hubrecht Institute in the Netherlands and the FLI-Leibniz Institute on Ageing in Jena.

We are looking for a curiosity-driven student that works both independently and as part of a team and is interested in a multi-disciplinary research project. The ideal candidate should have knowledge of molecular biology techniques such as DNA/RNA-isolation, PCR and cloning as well as cell culture. Additional experience in either Drosophila husbandry and genetics, immunohistochemistry and confocal microscopy would be an advantage. Excellent writing and communication skills in English are necessary.

Funding options:

This scholarship includes a doctoral stipend (equivalent to the Research Councils UK National Minimum Doctoral Stipend for 2021/2022 of £15,609), tuition fees at the home UK rate, £3,600 consumables funding, free access to all departmental equipment and access to further research funding.

In order to be considered for this position you must have qualifications/experience equal to the standard of a good honours degree at a first or upper second class level from a UK academic research organisation. Degree qualifications gained from outside the UK, or a combination of qualifications and/or experience that is equivalent to a relevant UK degree, may be accepted.

UK residential conditions:

  • Be a UK National (meeting UKRI residency requirements), or
  • Have settled status, or
  • Have pre-settled status (meeting residency requirement) or
  • Have indefinite leave to remain or enter

If you are applying as an overseas student (this includes EU nationals), overseas fee rates will be applicable.

How to Apply:

Email contact: studypgnats@kent.ac.uk

You will need to apply through the online application form on the main University website. Please note that you will be expected to provide personal details, education and employment history and supporting documentation (Curriculum Vitae, transcript of results, two academic references).

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

PhD tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
 
More PhDs from University of Kent

Show all PhDs for this organisation …

More PhDs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge