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Postdoctoral Research Assistant

University of Oxford

Location: Oxford
Salary: £34,308 to £42,155 per annum. Grade 7
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 29th November 2022
Closes: 9th January 2023
Job Ref: 161312

Location: Wood Group, Institute of Developmental and Regenerative Medicine (IDRM), Department of Paediatrics, University of Oxford

Salary: Grade 7: £34,308 - £42,155 per annum (with a discretionary range to £46,047 per annum)

Applications are invited for a Postdoctoral Research Scientist to collaborate in the project entitled “Developing a Cas13 approach to treat Friedreich Ataxia”, in the lab of A/P Carlo Rinaldi. The successful applicant will work to acquire data utilising highly novel methods of gene modulation, with the overall aim of treating FA and other neurological diseases caused by a similar mechanism of toxicity. The main mechanism-of-action relates to RNA modulation. Cas13 and guides will be designed and tested in cell model systems, before moving to appropriate in vivo models. The post holder is expected to collect and analyse data independently, adapt existing and develop new experimental protocols and collaborate in the preparation of scientific reports, within the guidance provided by senior colleagues. The appointed candidate will also be expected to carry out collaborative projects, provide advice and guidance to research students, where appropriate and ensure that all work is conducted safely. 

The role requires the applicant to have a doctoral degree (PhD, DPhil or equivalent) in biochemistry, molecular biology, genetics, physiology or a related discipline, and relevant practical working experience in a laboratory is essential. The applicant should be highly motivated, have an interest in molecular therapies, and be able to communicate effectively with others. Applicants must have experience in the majority of the following: mammalian cell culture techniques, design and use of Cas13 technology, and standard molecular biology methods (e.g. recombinant DNA technology, western blot, RT-qPCR etc.). Experience with the use of neuronal cell lines, animal experimentation in mice, and RNA editing is highly desirable. 

Applicants who fulfil the majority of the criteria are encouraged to apply. The post is offered full time on a fixed-term contract until July 2023 funded by the Christina Foundation.

This role meets the criteria for a UK Skilled Worker visa.

Application Process

You will be required to upload a CV and Supporting Statement as part of your online application. The Supporting Statement should include a cover letter and should also clearly describe how you meet each of the selection criteria listed in the job description. Click here for information and advice on writing an effective Supporting Statement.

To discuss the post in more detail, please contact Carlo Rinaldi, Associate Professor, using the contact details below.

Only online applications received before 12.00 midday on Monday 9 January 2023 will be considered. Interviews will be held as soon as possible thereafter.

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