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Research Fellow in Computational Genomics

UCL - Health and Medical

Location: London
Salary: £38,308 to £41,474 Please also note maximum salary is up to £41,474 pa, inclusive of London Allowance
Hours: Full Time
Contract Type: Permanent
Placed On: 2nd December 2022
Closes: 1st January 2023
Job Ref: B02-04152

About us The UCL Great Ormond Street Institute of Child Health (GOS ICH) The mission of the UCL GOS Institute of Child Health is to improve the health and well-being of children, and the adults they will become, through world-class research, education and public engagement. The UCL GOS ICH, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. The Institute offers world-class education and training across a wide range of teaching and life learning programmes which address the needs of students and professional groups who are interested in and undertaking work relevant to child health. GOS ICH holds an Athena SWAN Charter Gold Award.

About the role Genomics has shown great potential in the diagnosis, treatment and general understanding of human rare diseases. This is because novel genomic technologies allow u! s to iden tify the genetic basis of disease and its molecular mechanisms. These technologies include short- and long-read sequencing, single-cell in many flavours (genome and exome sequencing, RNA-seq, CITE-seq, Chip-seq, ATAC-seq…), spatial transcriptomics and 3D chromatin interactions (4-C and Hi-C). These technologies help diagnose patients that go otherwise undiagnosed as well as characterising in vitro (iPSC and organoid) and in vivo models of rare disease. Ultimately, we aim to translate these advances into the NHS and use the information these tools provide to individualise patient treatment. The data generated by these technologies, however, is large and complex and often combined with mass spec, imaging, patients’ medical records and other types of data to provide a multiomics and phenotypic view of rare disease. Specifically, new algorithms, including machine learning ones, need to be designed and new software tools to be developed, especially for the technolo! gies that have not yet reached the NHS. We are thus seeking to appoint a creative and highly motivated researcher with prime interest in computational genomics of rare disease. This is a unique opportunity to stand at the intersection of method development and its clinical application. This study is designed to investigate pathologies associated with the placental interface of maternal and fetal cells. Preliminary data is available for immediate analysis. This post is available until 31 August 2024, in the first instance.

About you Candidates should have a quantitative PhD in related genomic disciplines, including bioinformatics, computer science, statistics, molecular biology and applied mathematics, or equivalent experience. The ideal candidate will have experience in high-throughput genomics, a strong interest in single cell and spatial transcriptomics, and some experience in multiomics analyses. Previous work in translational medicine is a plus. Experience with ! large-sca le genomic datasets and databases, next-generation sequencing, functional data, and programming are a plus. The successful candidate will have the opportunity to contribute to multiple cutting-edge projects in child health and will work cooperatively with other group members and collaborators. The successful candidate will also have the opportunity to contribute computational methods to UCL Genomics, the genomics UCL core facility.

What we offer Visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more. Our commitment to Equality, Diversity and Inclusion At GOS ICH we aim to always have a balanced interview panel that is representative of gender and ethnic diversity. If you have any queries regarding the application process, please contact Madhur Sharma on quoting job reference




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